Sofie J. Nielsen, Bodil H. Bech, Katrine Strandberg-Larsen, Eva Bølling-Ladegaard, Chris Cotsapas, Jakob Christensen, Julie W. Dreier
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Adjusted odds ratios (aORs) with corresponding 95% confidence intervals (CIs) for the association between childhood seizures and internalizing symptoms (symptom score ≥8) and psychotic-like experiences (≥2 definite experiences) were obtained using logistic regression models.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 1620 children with febrile seizures (3.6%), and 311 children with epilepsy (0.7%) were identified. When adjusted for potential confounders, no association between febrile seizures and psychiatric symptoms was observed, and no association was observed between epilepsy and psychotic-like experiences. However, the OR for internalizing symptoms was 1.76 (95% CI: 1.20–2.58) in children with epilepsy compared to children without. This higher risk was evident mainly in boys (OR 2.30, 95% CI 1.37–3.85), children with ≥2 epilepsy-related hospital admissions (OR 2.79, 95% CI 1.81–4.32), and children whose age at first epilepsy-related hospital admission was 0–3 years (OR 2.47, 95% CI 1.45–4.19).</p>\n </section>\n \n <section>\n \n <h3> Significance</h3>\n \n <p>No association was found between febrile seizures and psychiatric symptoms or epilepsy and psychotic-like experiences at age 11. 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引用次数: 0
摘要
目的评估发热性癫痫发作和/或癫痫儿童在 11 岁时出现内化症状或类似精神病经历的风险是否会增加:这项队列研究包括丹麦国家出生队列 11 年随访中的 44 819 名儿童。有关儿童癫痫发作的信息来自丹麦国家患者登记处,而儿童精神症状则是通过青少年精神病样症状筛选器和优势与困难问卷的网络问卷进行评估的。使用逻辑回归模型得出了儿童癫痫发作与内化症状(症状评分≥8分)和精神病样经历(≥2次明确经历)之间的调整后几率比(aORs)及相应的95%置信区间(CIs):结果:共发现1620名发热性癫痫发作患儿(3.6%)和311名癫痫患儿(0.7%)。在对潜在的混杂因素进行调整后,未发现发热性癫痫发作与精神症状之间存在关联,也未发现癫痫与精神病样经历之间存在关联。然而,与无癫痫儿童相比,有癫痫儿童的内化症状OR值为1.76(95% CI:1.20-2.58)。这种较高的风险主要表现在男孩(OR 2.30,95% CI 1.37-3.85)、癫痫相关入院次数≥2次的儿童(OR 2.79,95% CI 1.81-4.32)以及首次癫痫相关入院年龄为0-3岁的儿童(OR 2.47,95% CI 1.45-4.19):11岁时发热性癫痫发作与精神症状或癫痫与精神病样经历之间没有关联。然而,患有癫痫的男孩出现内化症状的风险较高。
Febrile seizures and childhood epilepsy and risk of internalizing and psychotic symptoms
Objective
To assess whether children with febrile seizures and/or epilepsy were at increased risk of experiencing internalizing symptoms or psychotic-like experiences at age 11 years.
Methods
This cohort study includes 44 819 children from the 11-year follow up of the Danish National Birth Cohort. Information on childhood seizures was retrieved from the Danish National Patient Registry, whereas child psychiatric symptoms were assessed in a web-based questionnaire using the Adolescent Psychotic-like Symptom Screener and the Strength and Difficulties Questionnaire. Adjusted odds ratios (aORs) with corresponding 95% confidence intervals (CIs) for the association between childhood seizures and internalizing symptoms (symptom score ≥8) and psychotic-like experiences (≥2 definite experiences) were obtained using logistic regression models.
Results
A total of 1620 children with febrile seizures (3.6%), and 311 children with epilepsy (0.7%) were identified. When adjusted for potential confounders, no association between febrile seizures and psychiatric symptoms was observed, and no association was observed between epilepsy and psychotic-like experiences. However, the OR for internalizing symptoms was 1.76 (95% CI: 1.20–2.58) in children with epilepsy compared to children without. This higher risk was evident mainly in boys (OR 2.30, 95% CI 1.37–3.85), children with ≥2 epilepsy-related hospital admissions (OR 2.79, 95% CI 1.81–4.32), and children whose age at first epilepsy-related hospital admission was 0–3 years (OR 2.47, 95% CI 1.45–4.19).
Significance
No association was found between febrile seizures and psychiatric symptoms or epilepsy and psychotic-like experiences at age 11. However, boys with epilepsy were at higher risk of experiencing internalizing symptoms.
期刊介绍:
Epilepsia is the leading, authoritative source for innovative clinical and basic science research for all aspects of epilepsy and seizures. In addition, Epilepsia publishes critical reviews, opinion pieces, and guidelines that foster understanding and aim to improve the diagnosis and treatment of people with seizures and epilepsy.