糖尿病患者长期服用二甲双胍与维生素 B12 缺乏症。

IF 1.1 Q4 PHARMACOLOGY & PHARMACY
Md Sadique Hussain, Nitya Srivastava, Gurvinder Singh, Rajesh Kumar
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引用次数: 0

摘要

这篇内容广泛的综述深入探讨了糖尿病患者长期服用二甲双胍与可能出现维生素 B12 缺乏症(VB12D)之间的复杂关系。二甲双胍是糖尿病治疗的关键因素之一,它经常与维生素 B12 吸收减少联系在一起,从而引发了人们对这种相互作用的持久后果的担忧。这篇综述系统地综合了当前的证据,阐明了持续服用二甲双胍所导致的维生素 B12D 的发病率、机制和临床影响。该综述探讨了二甲双胍可能干扰维生素 B12 吸收的不同途径,包括干扰钙依赖膜活性和改变肠道中的微生物群。该书对实验研究和人体试验进行了细致分析,强调了在不同人群和年龄组中长期服用二甲双胍的个体中普遍存在不同的维生素 B12D。系统地研究了钴胺素缺乏症的临床表现,包括血液学异常和神经系统并发症。此外,综述还深入探讨了二甲双胍引起的钴胺素缺乏症对糖尿病相关并发症和患者整体健康的潜在影响。这篇综述全面概述了糖尿病患者使用二甲双胍与维生素 B12 缺乏之间错综复杂的相互作用,强调了常规监测、早期检测和个性化干预的重要性,以优化二甲双胍治疗糖尿病的长期安全性和有效性。报告还提出了未来的研究方向,以完善临床指南,加深对糖尿病、二甲双胍和维生素 B12 之间相关性的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-Term Use of Metformin and Vitamin B12 Deficiency in Diabetes.

This extensive review delves into the complex relationship between prolonged use of metformin and the possible emergence of vitamin B12 deficiency (VB12D) in diabetic patients. Metformin, a pivotal element in diabetes management, is constantly linked with decreased absorption of vitamin B12, prompting concerns about the enduring consequences of this interaction. The review systematically amalgamates current evidence, elucidating the prevalence, mechanisms, and clinical ramifications of VB12D induced by consistent consumption of metformin. Exploring the different pathways through which metformin might disrupt the absorption of Vitamin B12, the review encompasses interference with the calcium-dependent membrane activity and alterations of the microbiota present in the gut. A meticulous analysis of experimental studies and human trials is undertaken, accentuating the prevalence of variable VB12D among individuals on long-duration treatment of metformin across diverse populations and age groups. Clinical indications of cobalamin deficiency, spanning haematological abnormalities to neurological complications, are systematically examined. Furthermore, the review delves into the potential implications of cobalamin deficiency associated with metformin on diabetes-related complications and overall patient health. This review offers a comprehensive overview of the intricate interplay between the use of metformin and deficiency of vitamin B12 in diabetic patients, emphasizing the importance that lies in routine monitoring, early detection, and personalized interventions to optimize the long-period safety and efficiency of metformin in the treatment of diabetes. It also proposes future research directions to refine clinical guidelines and enhance the understanding regarding the correlation between diabetes, metformin, and vitamin B12.

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来源期刊
Current drug safety
Current drug safety PHARMACOLOGY & PHARMACY-
CiteScore
2.10
自引率
0.00%
发文量
112
期刊介绍: Current Drug Safety publishes frontier articles on all the latest advances on drug safety. The journal aims to publish the highest quality research articles, reviews and case reports in the field. Topics covered include: adverse effects of individual drugs and drug classes, management of adverse effects, pharmacovigilance and pharmacoepidemiology of new and existing drugs, post-marketing surveillance. The journal is essential reading for all researchers and clinicians involved in drug safety.
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