类风湿性关节炎与左心室舒张功能障碍的关系：发病机制、预测因素和处理方法。

IF 3.4 4区医学 Q2 RHEUMATOLOGY

Clinical and experimental rheumatology Pub Date : 2025-01-01 Epub Date: 2024-08-20 DOI:10.55563/clinexprheumatol/kmmkj7

Yezhou Qian, Bin Zhang, Feige Nian

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引用次数: 0

摘要

左心室舒张功能障碍（LVDD）在射血分数保留型心力衰竭（HFpEF）的病理生理学中起着核心作用，而射血分数保留型心力衰竭是心力衰竭（HF）的一种主要表现形式。低度炎症反应是导致 LVDD 的关键机制。类风湿性关节炎（RA）是一种全身性炎症性疾病，影响着 0.5-1.0% 的成年人群。多项流行病学研究发现，类风湿性关节炎患者发生低密度脂蛋白血症的风险高于普通人群。由于炎症在心血管疾病的发病机制中起着重要作用，而 RA 是一种以慢性全身性炎症为特征的疾病。RA可能与心血管缺损的发生和发展有关。本综述总结了 RA 患者 LVDD 的发病机制、预测因素和处理方法。

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The association between rheumatoid arthritis and left ventricular diastolic dysfunction: pathogenesis, predictors and managements.

Left ventricular diastolic dysfunction (LVDD) plays a central role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF), a major manifestation of heart failure (HF). Low-grade inflammatory reaction is the key mechanism leading to LVDD. Rheumatoid arthritis (RA) is a systemic inflammatory disease and affects 0.5-1.0% of the adult population. Several epidemiologic studies find that the risk of LVDD is increased in RA than in the general population. Since inflammation plays an important role in the pathogenesis of LVDD and RA is a disease characterised by chronic systemic inflammation. RA may be involved in the occurrence and development of LVDD. This review summarises the pathogenesis, predictors, and management of LVDD in patients with RA.

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来源期刊

Clinical and experimental rheumatology 医学-风湿病学

CiteScore

6.10

自引率

18.90%

发文量

377

审稿时长

3-6 weeks

期刊介绍： Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.