抗磷脂综合征患者体内的氧化低密度脂蛋白和抗氧化低密度脂蛋白抗体。

IF 3.4 4区 医学 Q2 RHEUMATOLOGY
Yongjing Luo, Lei Zhu, Xiaoyan Xing, Yunshan Zhou, Yuzhou Gan, Chun Li
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引用次数: 0

摘要

目的:复发性血栓形成是抗磷脂综合征(APS)的主要临床特征之一,最近的研究发现,APS与动脉粥样硬化有着相似的病理生理机制。氧化低密度脂蛋白(OxLDL)和抗氧化低密度脂蛋白抗体(anti-OxLDL)参与了动脉粥样硬化的发展。本研究旨在探讨氧化低密度脂蛋白和抗氧化低密度脂蛋白在 APS 患者中的临床意义:方法:共招募了 170 名 APS 患者和 39 名健康对照组(HC)。临床和实验室数据来自北京大学人民医院临床数据中心。使用酶联免疫吸附试验检测氧化低密度脂蛋白和抗氧化低密度脂蛋白:结果:在170例APS患者中,106例为孤立性血栓性APS。与 HC 相比,APS 患者的 OxLDL 滴度更高[413.86(220.11-853.67)纳克/毫升 vs. 45.54(0-105.98)纳克/毫升,p结论:本研究表明,抗 OxLDL 的存在可作为 APS 患者静脉血栓形成的潜在标志物。OxLDL和抗OxLDL可作为监测APS的重要生物标记物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxidised low-density lipoprotein and antibodies against oxidised low-density lipoprotein in patients with antiphospholipid syndrome.

Objectives: Recurrent thrombosis is one of the main clinical features of antiphospholipid syndrome (APS), and recent studies revealed that APS shares similar pathophysiological mechanisms with atherosclerosis. Oxidised low-density lipoprotein (OxLDL) and antibodies against OxLDL (anti-OxLDL) are involved in the development of atherosclerosis. This study aims to investigate the clinical significance of OxLDL and anti-OxLDL in APS patients.

Methods: One hundred and seventy APS patients and 39 healthy controls (HC) were enrolled. Clinical and laboratory data were collected from Clinical Data Center of Peking University People's Hospital. OxLDL and anti-OxLDL were detected using enzyme-linked immunosorbent assay.

Results: Among the 170 APS patients, 106 had isolated thrombotic APS. Compared with HC, APS patients exhibited higher titres of OxLDL [413.86 (220.11-853.67) ng/mL vs. 45.54 (0-105.98) ng/mL, p<0.001] and anti-OxLDL [107.62 (75.68-174.18) U/L vs. 44.13 (18.44-79.76) U/L, p<0.001]. Also, APS patients exhibited a higher positivity rate for OxLDL (88.2% vs. 5.1%, p<0.001) and anti-OxLDL (84.1% vs. 36.5%, p<0.001) compared to HC. APS patients with elevated levels of OxLDL had a higher rate of LAC positivity (68.0% vs. 45.0%, p=0.042). Furthermore, APS patients with positive anti-OxLDL demonstrated a higher occurrence of venous thrombosis (46.2% vs. 18.5%, p=0.008) and a lower rate of Coomb's test positivity (52.6% vs. 76.2%, p=0.049). Multivariate logistic regression revealed that anti-OxLDL positivity (OR 12.424, 95%CI 1.108-139.330, p=0.041) were risk factors for venous thrombotic APS.

Conclusions: This study indicates that the presence of anti-OxLDL may serve as potential markers for venous thrombosis in APS patients. OxLDL and anti-OxLDL may function as valuable biomarkers for monitoring APS.

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来源期刊
CiteScore
6.10
自引率
18.90%
发文量
377
审稿时长
3-6 weeks
期刊介绍: Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.
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