从甘油三酯血糖指数看环境重金属暴露与相关心血管疾病

IF 3.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiovascular Toxicology Pub Date : 2024-11-01 Epub Date: 2024-08-30 DOI:10.1007/s12012-024-09913-x
Muhammad Bilal Sardar, Mohsin Raza, Ammara Fayyaz, Muhammad Asfandyar Nadir, Zain Ali Nadeem, Muhammad Babar
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引用次数: 0

摘要

心血管疾病(CVD),主要是缺血性心脏病和中风,仍然是全球主要的健康负担。环境风险因素在心血管疾病的发病中起着重要作用,尤其是重金属暴露。甘油三酯血糖指数(TyG)是衡量胰岛素抵抗和心血管疾病风险的指标,是本研究的重点,它总结了铅(Pb)、砷(As)和镉(Cd)对心血管疾病风险影响的最新发现。较高的心血管疾病风险与TyG指数升高有关,而TyG指数升高与胰岛素抵抗有关。接触镉会导致脂质代谢紊乱和氧化应激,从而增加心血管疾病和 TyG 风险。接触镉会减少胰岛素分泌和信号传导,从而提高TyG指数并导致血脂异常。铅暴露会导致氧化应激和胰腺β细胞破坏,从而增加心血管疾病和TyG指数的风险。这些结果凸显了通过改变生活方式和环境来减少重金属暴露以降低心血管疾病风险的必要性。要了解重金属危害健康的机制并制定切实可行的管理计划,还需要进行更多的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Environmental Heavy Metal Exposure and Associated Cardiovascular Diseases in Light of the Triglyceride Glucose Index.

Environmental Heavy Metal Exposure and Associated Cardiovascular Diseases in Light of the Triglyceride Glucose Index.

Cardiovascular diseases (CVD), primarily ischemic heart disease and stroke, remain leading global health burdens. Environmental risk factors have a major role in the development of CVD, particularly exposure to heavy metals. The Triglyceride Glucose Index (TyG), a measure of insulin resistance and CVD risk, is the primary focus of this study, which summarizes the most recent findings on the effects of lead (Pb), arsenic (As), and cadmium (Cd) on CVD risk. A higher risk of CVD is correlated with an elevated TyG index, which has been linked to insulin resistance. Exposure to Cd is associated with disturbance of lipid metabolism and oxidative stress, which increases the risk of CVD and TyG. Exposure reduces insulin secretion and signaling, which raises the TyG index and causes dyslipidemia. Pb exposure increases the risk of CVD and TyG index via causing oxidative stress and pancreatic β-cell destruction. These results highlight the need of reducing heavy metal exposure by lifestyle and environmental modifications in order to lower the risk of CVD. To comprehend the mechanisms and create practical management plans for health hazards associated with heavy metals, more study is required.

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来源期刊
Cardiovascular Toxicology
Cardiovascular Toxicology 医学-毒理学
CiteScore
6.60
自引率
3.10%
发文量
61
审稿时长
>12 weeks
期刊介绍: Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.
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