早发 2 型糖尿病表现的种族差异。

IF 3.7 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

BMJ Open Diabetes Research & Care Pub Date : 2024-08-29 DOI:10.1136/bmjdrc-2024-004174

Davis Kibirige, Jean-Claude Katte, Anita V Hill, Isaac Sekitoleko, William Lumu, Julieanne Knupp, Steven Squires, Andrew T Hattersley, Liam Smeeth, Angus G Jones, Moffat J Nyirenda

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引用次数: 0

摘要

简介：我们对新近确诊的非洲黑人和欧洲白人成年 2 型糖尿病（T2D）患者的早发和晚发 2 型糖尿病（T2D）进行了表型鉴定，以探索早发 T2D 的种族差异：利用乌干达糖尿病表型研究队列中的 500 名成年乌干达人和英国 StartRight 研究队列中的 714 名近期诊断为胰岛自身抗体阴性 T2D 的欧洲白人，我们比较了早发 T2D 参与者（诊断时间为结果）的表型特征：134名乌干达成年人和113名欧洲白人患有早发T2D。与晚发型 T2D 相比，欧洲白人中的早发型 T2D 患者以女性为主（52.2% vs 39.1%，p=0.01），体重指数增加（平均值（95% CI）36.7 (35.2-38.1) kg/m2 vs 33.0 (32.4-33.6) kg/m2，p2 vs 27.9 (27.3-28.5) kg/m2，p=0.29）：结论：早发 T2D 在表现形式上的这些差异凸显了针对不同种族和人群的治疗和预防方法的必要性。

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Ethnic differences in the manifestation of early-onset type 2 diabetes.

Introduction: We undertook phenotypic characterization of early-onset and late-onset type 2 diabetes (T2D) in adult black African and white European populations with recently diagnosed T2D to explore ethnic differences in the manifestation of early-onset T2D.

Research design and methods: Using the Uganda Diabetes Phenotype study cohort of 500 adult Ugandans and the UK StartRight study cohort of 714 white Europeans with recently diagnosed islet autoantibody-negative T2D, we compared the phenotypic characteristics of participants with early-onset T2D (diagnosed at <40 years) and late-onset T2D (diagnosed at ≥40 years).

Results: One hundred and thirty-four adult Ugandans and 113 white Europeans had early-onset T2D. Compared with late-onset T2D, early-onset T2D in white Europeans was significantly associated with a female predominance (52.2% vs 39.1%, p=0.01), increased body mass index (mean (95% CI) 36.7 (35.2-38.1) kg/m² vs 33.0 (32.4-33.6) kg/m², p<0.001), waist circumference (112.4 (109.1-115.6) cm vs 108.8 (107.6-110.1) cm, p=0.06), and a higher frequency of obesity (82.3% vs 63.4%, p<0.001). No difference was seen with the post-meal C-peptide levels as a marker of beta-cell function (mean (95% CI) 2130.94 (1905.12-2356.76) pmol/L vs 2039.72 (1956.52-2122.92), p=0.62).In contrast, early-onset T2D in Ugandans was associated with less adiposity (mean (95% CI) waist circumference 93.1 (89.9-96.3) cm vs 97.4 (95.9-98.8) cm, p=0.006) and a greater degree of beta-cell dysfunction (120 min post-glucose load C-peptide mean (95% CI) level 896.08 (780.91-1011.24) pmol/L vs 1310.10 (1179.24-1440.95) pmol/L, p<0.001), without female predominance (53.0% vs 57.9%, p=0.32) and differences in the body mass index (mean (95% CI) 27.3 (26.2-28.4) kg/m² vs 27.9 (27.3-28.5) kg/m², p=0.29).

Conclusions: These differences in the manifestation of early-onset T2D underscore the need for ethnic-specific and population-specific therapeutic and preventive approaches for the condition.

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来源期刊

BMJ Open Diabetes Research & Care Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

9.30

自引率

2.40%

发文量

123

审稿时长

18 weeks

期刊介绍： BMJ Open Diabetes Research & Care is an open access journal committed to publishing high-quality, basic and clinical research articles regarding type 1 and type 2 diabetes, and associated complications. Only original content will be accepted, and submissions are subject to rigorous peer review to ensure the publication of high-quality — and evidence-based — original research articles.