{"title":"金-198 近距离放射治疗剂量分析计算方法的可行性","authors":"","doi":"10.1016/j.ejmp.2024.104501","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>A dose calculation algorithm Computed Tomography (CT)-based analytical dose calculation method (CT<sub>anly</sub>), which can correct for subject inhomogeneity and size-dependent scatter doses, was applied to the <sup>198</sup>Au seed. In this study, we evaluated the effectiveness of the CT<sub>anly</sub> method by comparing the gold standard Monte Carlo (MC) method and the conventional TG43 method on two virtual phantoms and patient CT images simulating oral cancer.</p></div><div><h3>Methods</h3><p>As virtual phantoms, a water phantom and a heterogeneous phantom with soft tissue inserted cubic fat, lung, and bone were used. A 2-mm-thick lead plate was also inserted into the heterogeneous phantom as a dose attenuator. Virtual <sup>198</sup>Au seeds and a 2-mm-thick lead plate were placed on the patient CT images. Dose distributions obtained via the TG43 and CT<sub>anly</sub> methods were compared with those of the MC by gamma analysis with 2%/2-mm thresholds. The computation durations were also compared.</p></div><div><h3>Results</h3><p>In the water phantom, dose distributions comparable to those obtained via the MC method were obtained regardless of the algorithm. For the inhomogeneity phantom and patient case, the CT<sub>anly</sub> method showed an improvement in the gamma passing rate and dose distributions similar to those of the MC method were obtained. The computation time, which was days with the MC method, was reduced to minutes with the CT<sub>anly</sub> method.</p></div><div><h3>Conclusions</h3><p>The CT<sub>anly</sub> method is effective for <sup>198</sup>Au seed dose calculations and takes a shorter time to obtain the dose distributions than the MC method.</p></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1120179724002461/pdfft?md5=1085468ddc0be672af09430479818c3a&pid=1-s2.0-S1120179724002461-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Feasibility of the analytical dose calculation method for Au-198 brachytherapy\",\"authors\":\"\",\"doi\":\"10.1016/j.ejmp.2024.104501\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>A dose calculation algorithm Computed Tomography (CT)-based analytical dose calculation method (CT<sub>anly</sub>), which can correct for subject inhomogeneity and size-dependent scatter doses, was applied to the <sup>198</sup>Au seed. In this study, we evaluated the effectiveness of the CT<sub>anly</sub> method by comparing the gold standard Monte Carlo (MC) method and the conventional TG43 method on two virtual phantoms and patient CT images simulating oral cancer.</p></div><div><h3>Methods</h3><p>As virtual phantoms, a water phantom and a heterogeneous phantom with soft tissue inserted cubic fat, lung, and bone were used. A 2-mm-thick lead plate was also inserted into the heterogeneous phantom as a dose attenuator. Virtual <sup>198</sup>Au seeds and a 2-mm-thick lead plate were placed on the patient CT images. Dose distributions obtained via the TG43 and CT<sub>anly</sub> methods were compared with those of the MC by gamma analysis with 2%/2-mm thresholds. The computation durations were also compared.</p></div><div><h3>Results</h3><p>In the water phantom, dose distributions comparable to those obtained via the MC method were obtained regardless of the algorithm. For the inhomogeneity phantom and patient case, the CT<sub>anly</sub> method showed an improvement in the gamma passing rate and dose distributions similar to those of the MC method were obtained. The computation time, which was days with the MC method, was reduced to minutes with the CT<sub>anly</sub> method.</p></div><div><h3>Conclusions</h3><p>The CT<sub>anly</sub> method is effective for <sup>198</sup>Au seed dose calculations and takes a shorter time to obtain the dose distributions than the MC method.</p></div>\",\"PeriodicalId\":56092,\"journal\":{\"name\":\"Physica Medica-European Journal of Medical Physics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1120179724002461/pdfft?md5=1085468ddc0be672af09430479818c3a&pid=1-s2.0-S1120179724002461-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physica Medica-European Journal of Medical Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1120179724002461\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physica Medica-European Journal of Medical Physics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1120179724002461","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
目的 一种剂量计算算法 基于计算机断层扫描(CT)的分析剂量计算方法(CTanly)被应用于 198Au 种子,该方法可以校正受试者的不均匀性和与尺寸相关的散射剂量。在这项研究中,我们在两个虚拟模型和模拟口腔癌的患者 CT 图像上比较了金标准蒙特卡罗(MC)方法和传统的 TG43 方法,评估了 CTanly 方法的有效性。异质模型中还插入了一块 2 毫米厚的铅板作为剂量衰减器。在患者 CT 图像上放置了虚拟 198Au 种子和 2 毫米厚的铅板。在 2%/2 毫米阈值下,通过伽马分析将 TG43 和 CTanly 方法获得的剂量分布与 MC 方法的剂量分布进行了比较。结果在水模型中,无论采用哪种算法,都能获得与 MC 方法相当的剂量分布。对于不均匀模型和患者病例,CTanly 方法提高了伽马通过率,得到的剂量分布与 MC 方法相似。结论 CTanly 方法对 198Au 种子剂量计算很有效,与 MC 方法相比,它能在更短的时间内获得剂量分布。
Feasibility of the analytical dose calculation method for Au-198 brachytherapy
Purpose
A dose calculation algorithm Computed Tomography (CT)-based analytical dose calculation method (CTanly), which can correct for subject inhomogeneity and size-dependent scatter doses, was applied to the 198Au seed. In this study, we evaluated the effectiveness of the CTanly method by comparing the gold standard Monte Carlo (MC) method and the conventional TG43 method on two virtual phantoms and patient CT images simulating oral cancer.
Methods
As virtual phantoms, a water phantom and a heterogeneous phantom with soft tissue inserted cubic fat, lung, and bone were used. A 2-mm-thick lead plate was also inserted into the heterogeneous phantom as a dose attenuator. Virtual 198Au seeds and a 2-mm-thick lead plate were placed on the patient CT images. Dose distributions obtained via the TG43 and CTanly methods were compared with those of the MC by gamma analysis with 2%/2-mm thresholds. The computation durations were also compared.
Results
In the water phantom, dose distributions comparable to those obtained via the MC method were obtained regardless of the algorithm. For the inhomogeneity phantom and patient case, the CTanly method showed an improvement in the gamma passing rate and dose distributions similar to those of the MC method were obtained. The computation time, which was days with the MC method, was reduced to minutes with the CTanly method.
Conclusions
The CTanly method is effective for 198Au seed dose calculations and takes a shorter time to obtain the dose distributions than the MC method.
期刊介绍:
Physica Medica, European Journal of Medical Physics, publishing with Elsevier from 2007, provides an international forum for research and reviews on the following main topics:
Medical Imaging
Radiation Therapy
Radiation Protection
Measuring Systems and Signal Processing
Education and training in Medical Physics
Professional issues in Medical Physics.