四嗪和炔基硫化物区域选择性合成哒嗪

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-08-29 DOI:10.1039/D4QO01286K

Chika Yamamoto, Koyo Numata, Minori Suzuki and Suguru Yoshida

引用次数: 0

摘要

本发明公开了一种由四嗪和炔基硫化物组成的三取代哒嗪的区域选择性合成方法。通过反电子需求的 Diels-Alder 反应和脱氮反应选择性地制备了各种哒嗪。硫取代基的良好转化性使我们能够合成一系列没有区域异构体的哒嗪。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Regioselective pyridazine synthesis from tetrazines and alkynyl sulfides†

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Regioselective pyridazine synthesis from tetrazines and alkynyl sulfides†

A regioselective synthesis of trisubstituted pyridazines from tetrazines and alkynyl sulfides is described. Various pyridazines were selectively prepared by the inverse-electron-demand Diels–Alder reaction and subsequent denitrogenation. Good transformability of sulfur substituents allowed us to synthesize a range of pyridazines without regioisomers.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.