疼痛和活动过度患者中枢敏感性清单分类的证据。

IF 2.5 3区医学 Q2 ANESTHESIOLOGY

Pain Practice Pub Date : 2024-08-27 DOI:10.1111/papr.13411

Mehul J Desai, Mason Brestle, Holly Jonely

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引用次数: 0

摘要

导言：疼痛是活动过度埃勒斯-丹洛斯综合征（hEDS）和活动过度频谱障碍（HSDs）患者的常见主诉。这类患者的疼痛往往难以治疗，对其疼痛根源的研究也是昙花一现。中枢敏化（CS）被认为是一个潜在的致病因素：在这项回顾性研究中，我们回顾了 82 名连续的 hEDS/HSD 患者。结果：82 名患者中有 71 人（86.5%）患有中枢性过敏反应：结果：82 位患者中有 71 位（86.5%）表现为 CS。评分范围为 12 到 94 分，中位数为 56 分。数字评分量表（NRS）显示的疼痛评分从 2 到 10 不等，平均值和中位数均为 6.Conclusion：结论：使用 CSI 测量，很大一部分被诊断为 hEDS/HSDs 的疼痛患者都有中枢敏化的证据。CSI 操作简单。CSI 可提供临床见解，是成功管理 hEDS/HSDs 患者的关键。还需要进一步的研究来探索对这类患者的疼痛表型进行分类的能力以及对精准医疗的影响。

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Evidence for central sensitization as classified by the central sensitization inventory in patients with pain and hypermobility.

Introduction: Pain is a very common complaint among patients with hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorders (HSDs). Often challenging to treat, insights into the underpinnings of pain in this population have been fleeting. Central sensitization (CS) has been postulated as a potential etiological factor.

Methods: In this retrospective study, 82 consecutive patients with hEDS/HSDs were reviewed. Demographic information and Central Sensitization Inventory (CSI) results were collected.

Results: 71 of 82 (86.5%) patients demonstrated CS. Scores ranged from 12 to 94 with a median of 56. Pain scores as measured on the numerical rating scale (NRS) ranged from 2 to 10 with a mean and median of 6.

Conclusion: A large percentage of patients with pain and a diagnosis of hEDS/HSDs demonstrated evidence of central sensitization as measured using the CSI. The CSI is simple to administer. The CSI may provide clinical insights that are key to successfully managing patients with hEDS/HSDs. Further research is needed to explore the ability to classify pain phenotypes in this patient population and the impact on precision medicine.

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来源期刊

Pain Practice ANESTHESIOLOGY-CLINICAL NEUROLOGY

CiteScore

5.60

自引率

3.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Pain Practice, the official journal of the World Institute of Pain, publishes international multidisciplinary articles on pain and analgesia that provide its readership with up-to-date research, evaluation methods, and techniques for pain management. Special sections including the Consultant’s Corner, Images in Pain Practice, Case Studies from Mayo, Tutorials, and the Evidence-Based Medicine combine to give pain researchers, pain clinicians and pain fellows in training a systematic approach to continuing education in pain medicine. Prior to publication, all articles and reviews undergo peer review by at least two experts in the field.