亲和战争：PSAT1 优于其他。

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2024-08-27 DOI:10.1038/s42255-024-01096-7

Richard Possemato

引用次数: 0

摘要

对谷氨酰胺限制的抵抗力是由丝氨酸合成增加所介导的。丝氨酸合成酶 PSAT1 对谷氨酸的高亲和力促使谷氨酰胺的持续利用。联合靶向途径限制了小鼠乳腺癌模型中肿瘤的生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Affinity war: PSAT1 outcompetes the rest

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Affinity war: PSAT1 outcompetes the rest

Resistance to glutamine restriction is mediated by increased serine synthesis. The high affinity of serine synthesis enzyme PSAT1 for glutamate drives sustained glutamine utilization. Combined pathway targeting limits tumour growth in mouse breast cancer models.

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.