识别逃避抗病毒先天免疫的病毒基因/蛋白的指导策略。

Q4 Biochemistry, Genetics and Molecular Biology

Methods in molecular biology Pub Date : 2025-01-01 DOI:10.1007/978-1-0716-4108-8_2

Hongjuan You, Chunfu Zheng

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引用次数: 0

摘要

抗病毒先天免疫是抵御病毒的第一道防线。干扰素（IFN）信号通路、DNA 损伤反应（DDR）、细胞凋亡、内质网（ER）应激和自噬都参与了抗病毒先天免疫。病毒以各种方式削弱细胞对复制的抗病毒免疫反应。病毒基因/蛋白在逃避抗病毒先天免疫中起着关键作用。在此，我们将讨论病毒对抗病毒先天免疫的干扰以及识别病毒基因/蛋白免疫逃避的策略。

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A Guideline Strategy for Identifying a Viral Gene/Protein Evading Antiviral Innate Immunity.

Antiviral innate immunity is the first line of defence against viruses. The interferon (IFN) signaling pathway, the DNA damage response (DDR), apoptosis, endoplasmic reticulum (ER) stress, and autophagy are involved in antiviral innate immunity. Viruses abrogate the antiviral immune response of cells to replication in various ways. Viral genes/proteins play a key role in evading antiviral innate immunity. Here, we will discuss the interference of viruses with antiviral innate immunity and the strategy for identifying viral gene/protein immune evasion.

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来源期刊

Methods in molecular biology Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

2.00

自引率

0.00%

发文量

3536

期刊介绍： For over 20 years, biological scientists have come to rely on the research protocols and methodologies in the critically acclaimed Methods in Molecular Biology series. The series was the first to introduce the step-by-step protocols approach that has become the standard in all biomedical protocol publishing. Each protocol is provided in readily-reproducible step-by-step fashion, opening with an introductory overview, a list of the materials and reagents needed to complete the experiment, and followed by a detailed procedure that is supported with a helpful notes section offering tips and tricks of the trade as well as troubleshooting advice.