表观遗传学鉴定 LTBP4 为乳腺癌的假定肿瘤抑制因子。

IF 3 4区医学 Q2 GENETICS & HEREDITY

Epigenomics Pub Date : 2024-01-01 Epub Date: 2024-08-28 DOI:10.1080/17501911.2024.2388017

Wenfeng He, Jingheng Zhang, Siyuan Wen, Ying Li, Lin Shen, Tiejun Zhou, Qinglian Wen, Yu Fan

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引用次数: 0

摘要

目的：探讨LTBP4在乳腺癌（BC）中的表达、预后意义和分子作用机制：方法：在omics数据集和实验的基础上，我们对LTBP4在BC中的表达进行了综合分析：结果与结论：LTBP4在启动子甲基化程度高、基因改变程度低的BC中被下调。DNA甲基化与LTBP4 mRNA表达呈负相关。LTBP4越高，生存率越高。LTBP4在细胞外基质受体相互作用、细胞粘附分子、细胞周期和MAPK通路中富集。LTBP4的表达和甲基化分别与肿瘤浸润免疫细胞呈正相关和负相关。总之，LTBP4是一种可能的肿瘤抑制因子，其表达受DNA甲基化调控，并与预后有关。

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Epigenetic identification of LTBP4 as a putative tumor suppressor in breast cancer.

Aim: To explore the LTBP4's expression, prognostic significance and molecular mechanism of action in breast cancer (BC).Methods: On the basis of omics datasets and experiments, we conducted a synthetical analysis of LTBP4 in BC.Results & conclusion: LTBP4 was downregulated in BC with high promoter methylation and low genetic alteration. DNA methylation was negatively associated with LTBP4 mRNA expression. Higher LTBP4 associated with better survival. LTBP4 was enrichment in extracellular matrix receptor interactions, cell adhesion molecules, cell cycle and MAPK pathway. LTBP4 expression and methylation were positively and negatively associated with tumor infiltrating immune cells, respectively. In conclusion, LTBP4 is a putative tumor suppressor in BC, which expression is regulated by DNA methylation and relates with prognosis.

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.