人类代谢性疾病中的 T 细胞衰老

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Diabetes & Metabolism Journal Pub Date : 2024-09-01 Epub Date: 2024-08-28 DOI:10.4093/dmj.2024.0140
Ha Thi Nga, Thi Linh Nguyen, Hyon-Seung Yi
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引用次数: 0

摘要

免疫衰老是指免疫细胞功能失调的一种状态,其特点是多种因素交织在一起,包括细胞周期停滞、端粒缩短、细胞应激标记物、线粒体功能障碍、蛋白稳态丧失、表观遗传学重编程和促炎介质分泌。这种状态主要表现在衰老过程中,但也可在各种病理情况下诱发,包括慢性病毒感染、自身免疫性疾病和代谢紊乱。与年龄相关的免疫系统改变延伸到先天性和适应性免疫细胞,T 细胞对免疫衰老表现出更高的易感性。特别是在肥胖、糖尿病和心血管疾病等代谢性疾病中发现了衰老的 T 细胞。最近的研究表明,T 细胞衰老、炎症和胰岛素抵抗之间存在直接联系。衰老 T 细胞对生物稳态的干扰似乎与代谢性疾病的发生和发展密切相关,尤其是通过炎症介导的胰岛素抵抗。因此,衰老 T 细胞正成为一个值得关注的治疗靶点。本综述旨在阐明代谢性疾病与 T 细胞衰老之间错综复杂的关系,深入探讨衰老 T 细胞在代谢性疾病发病机制中的潜在作用。通过对当前研究成果的全面审视,本综述旨在加深对免疫衰老与代谢健康之间复杂相互作用的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
T-Cell Senescence in Human Metabolic Diseases.

Immunosenescence denotes a state of dysregulated immune cell function characterized by a confluence of factors, including arrested cell cycle, telomere shortening, markers of cellular stress, mitochondrial dysfunction, loss of proteostasis, epigenetic reprogramming, and secretion of proinflammatory mediators. This state primarily manifests during the aging process but can also be induced in various pathological conditions, encompassing chronic viral infections, autoimmune diseases, and metabolic disorders. Age-associated immune system alterations extend to innate and adaptive immune cells, with T-cells exhibiting heightened susceptibility to immunosenescence. In particular, senescent T-cells have been identified in the context of metabolic disorders such as obesity, diabetes, and cardiovascular diseases. Recent investigations suggest a direct link between T-cell senescence, inflammation, and insulin resistance. The perturbation of biological homeostasis by senescent T-cells appears intricately linked to the initiation and progression of metabolic diseases, particularly through inflammation-mediated insulin resistance. Consequently, senescent T-cells are emerging as a noteworthy therapeutic target. This review aims to elucidate the intricate relationship between metabolic diseases and T-cell senescence, providing insights into the potential roles of senescent T-cells in the pathogenesis of metabolic disorders. Through a comprehensive examination of current research findings, this review seeks to contribute to a deeper understanding of the complex interplay between immunosenescence and metabolic health.

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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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