研究用于脉冲低剂量率放射治疗的直线加速器低剂量率模式。

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Mahmoud H Abdelgawad, Ahmed A Eldib, Tamer M Elsayed, Cm Charlie Ma
{"title":"研究用于脉冲低剂量率放射治疗的直线加速器低剂量率模式。","authors":"Mahmoud H Abdelgawad, Ahmed A Eldib, Tamer M Elsayed, Cm Charlie Ma","doi":"10.1088/2057-1976/ad73dd","DOIUrl":null,"url":null,"abstract":"<p><p><i>Purpose</i>. Pulsed volumetric modulated arc therapy (VMAT) was proposed as an advanced treatment that combines the biological benefits of pulsed low dose rate (PLDR) and the dosimetric benefits of the intensity-modulated beams. In our conventional pulsed VMAT technique, a daily fractional dose of 200 cGy is delivered in 10 arcs with 3 min intervals between the arcs. In this study, we are testing the feasibility of pulsed VMAT that omits the need to split into ten arcs and excludes any beam-off gaps.<i>Methods</i>. The study was conducted using computed tomographic images of 24 patients previously treated at our institution with the conventional PLDR technique. Our newly installed Elekta machine has a low dose rate option on the order of 25 MU min<sup>-1</sup>. PLDR requires an effective dose rate of 6.7 cGy min<sup>-1</sup>with attention being paid to the maximum dose received within any point within the target not to exceed 13 cGy min<sup>-1</sup>. The quality of treatment plans was judged based on dose-volume histograms, isodose distribution, dose conformality to the target, and target dose homogeneity. The dose delivery accuracy was assessed by measurements using the<i>MatriXX</i><sup><i>Evolution</i></sup>2D array system.<i>Results</i>. All cases were normalized to cover 95% of the target volume with 100% of the prescription dose. The average conformity index was 1.03 ± 0.08 while the average homogeneity index was 1.05 ± 0.02. The maximum reported dose rate at any point within the target was 10.44 cGy min<sup>-1</sup>. The mean dose rate for all pulsed VMAT plans was 6.88 ± 0.1 cGy min<sup>-1</sup>. All cases passed our gamma analysis with an average passing rate of 99.00% ± 0.48%.<i>Conclusion</i>. The study showed the applicability of planning pulsed VMAT using Eclipse and its successful delivery on our Elekta linac. Pulsed VMAT using the machine's low dose rate mode is more efficient than our previous pulsed VMAT delivery.</p>","PeriodicalId":8896,"journal":{"name":"Biomedical Physics & Engineering Express","volume":" ","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigation of the linear accelerator low dose rate mode for pulsed low-dose-rate radiotherapy delivery.\",\"authors\":\"Mahmoud H Abdelgawad, Ahmed A Eldib, Tamer M Elsayed, Cm Charlie Ma\",\"doi\":\"10.1088/2057-1976/ad73dd\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Purpose</i>. Pulsed volumetric modulated arc therapy (VMAT) was proposed as an advanced treatment that combines the biological benefits of pulsed low dose rate (PLDR) and the dosimetric benefits of the intensity-modulated beams. In our conventional pulsed VMAT technique, a daily fractional dose of 200 cGy is delivered in 10 arcs with 3 min intervals between the arcs. In this study, we are testing the feasibility of pulsed VMAT that omits the need to split into ten arcs and excludes any beam-off gaps.<i>Methods</i>. The study was conducted using computed tomographic images of 24 patients previously treated at our institution with the conventional PLDR technique. Our newly installed Elekta machine has a low dose rate option on the order of 25 MU min<sup>-1</sup>. PLDR requires an effective dose rate of 6.7 cGy min<sup>-1</sup>with attention being paid to the maximum dose received within any point within the target not to exceed 13 cGy min<sup>-1</sup>. The quality of treatment plans was judged based on dose-volume histograms, isodose distribution, dose conformality to the target, and target dose homogeneity. The dose delivery accuracy was assessed by measurements using the<i>MatriXX</i><sup><i>Evolution</i></sup>2D array system.<i>Results</i>. All cases were normalized to cover 95% of the target volume with 100% of the prescription dose. The average conformity index was 1.03 ± 0.08 while the average homogeneity index was 1.05 ± 0.02. The maximum reported dose rate at any point within the target was 10.44 cGy min<sup>-1</sup>. The mean dose rate for all pulsed VMAT plans was 6.88 ± 0.1 cGy min<sup>-1</sup>. All cases passed our gamma analysis with an average passing rate of 99.00% ± 0.48%.<i>Conclusion</i>. The study showed the applicability of planning pulsed VMAT using Eclipse and its successful delivery on our Elekta linac. Pulsed VMAT using the machine's low dose rate mode is more efficient than our previous pulsed VMAT delivery.</p>\",\"PeriodicalId\":8896,\"journal\":{\"name\":\"Biomedical Physics & Engineering Express\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical Physics & Engineering Express\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1088/2057-1976/ad73dd\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Physics & Engineering Express","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1088/2057-1976/ad73dd","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

摘要

目的:脉冲容积调制弧治疗(VMAT)是一种先进的治疗方法,它结合了脉冲低剂量率(PLDR)的生物学优势和强度调制射束的剂量学优势。在我们的传统脉冲 VMAT 技术中,每天的部分剂量为 200 cGy,分 10 次弧形照射,每次弧形照射间隔 3 分钟。在这项研究中,我们正在测试脉冲 VMAT 的可行性,它省去了分成 10 个弧形的需要,并排除了任何束离间隙:这项研究使用了我院之前使用传统 PLDR 技术治疗的 24 名患者的计算机断层扫描图像。我们新安装的 Elekta 设备具有低剂量率选项,约为 25MU/分钟。PLDR 要求有效剂量率为 6.7 cGy/分钟,并注意靶内任何一点的最大剂量不得超过 13 cGy/分钟。治疗计划的质量是根据剂量-体积直方图、等剂量分布、剂量与靶点的一致性以及靶点剂量的均匀性来判断的。通过使用 MatriXXEvolution 2D 阵列系统进行测量,评估了剂量投放的准确性:所有病例均以 100%的处方剂量覆盖 95% 的靶体积。平均一致性指数为 1.03 ± 0.08,平均均匀性指数为 1.05 ± 0.02。据报告,目标内任何一点的最大剂量率为 10.44 cGy/min。所有脉冲 VMAT 计划的平均剂量率为 6.88 ± 0.1 cGy/min。所有病例都通过了伽马分析,平均通过率为 99.00% ± 0.48%:这项研究表明,使用 Eclipse 规划脉冲 VMAT 是可行的,而且能在我们的 Elekta linac 上成功实施。使用机器的低剂量率模式进行脉冲 VMAT 比我们以前的脉冲 VMAT 给药更有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigation of the linear accelerator low dose rate mode for pulsed low-dose-rate radiotherapy delivery.

Purpose. Pulsed volumetric modulated arc therapy (VMAT) was proposed as an advanced treatment that combines the biological benefits of pulsed low dose rate (PLDR) and the dosimetric benefits of the intensity-modulated beams. In our conventional pulsed VMAT technique, a daily fractional dose of 200 cGy is delivered in 10 arcs with 3 min intervals between the arcs. In this study, we are testing the feasibility of pulsed VMAT that omits the need to split into ten arcs and excludes any beam-off gaps.Methods. The study was conducted using computed tomographic images of 24 patients previously treated at our institution with the conventional PLDR technique. Our newly installed Elekta machine has a low dose rate option on the order of 25 MU min-1. PLDR requires an effective dose rate of 6.7 cGy min-1with attention being paid to the maximum dose received within any point within the target not to exceed 13 cGy min-1. The quality of treatment plans was judged based on dose-volume histograms, isodose distribution, dose conformality to the target, and target dose homogeneity. The dose delivery accuracy was assessed by measurements using theMatriXXEvolution2D array system.Results. All cases were normalized to cover 95% of the target volume with 100% of the prescription dose. The average conformity index was 1.03 ± 0.08 while the average homogeneity index was 1.05 ± 0.02. The maximum reported dose rate at any point within the target was 10.44 cGy min-1. The mean dose rate for all pulsed VMAT plans was 6.88 ± 0.1 cGy min-1. All cases passed our gamma analysis with an average passing rate of 99.00% ± 0.48%.Conclusion. The study showed the applicability of planning pulsed VMAT using Eclipse and its successful delivery on our Elekta linac. Pulsed VMAT using the machine's low dose rate mode is more efficient than our previous pulsed VMAT delivery.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Biomedical Physics & Engineering Express
Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.80
自引率
0.00%
发文量
153
期刊介绍: BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信