克隆性造血的临床和治疗意义。

IF 7.7 2区 生物学 Q1 GENETICS & HEREDITY
Giulia Petrone, Isik Turker, Pradeep Natarajan, Kelly L Bolton
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引用次数: 0

摘要

克隆性造血(CH)是一种与年龄相关的过程,造血干细胞和祖细胞(HSPCs)通过突变获得增殖优势和克隆扩增。最常见的突变基因是表观遗传调节基因、DNA损伤反应基因和剪接因子,它们对维持造血干细胞的功能至关重要,并经常参与血液恶性肿瘤的发生。CH的既有风险因素包括年龄、既往接受过细胞毒治疗和吸烟,这些因素会增加罹患CH的风险和/或可能增加CH的患病率。在许多与年龄有关的疾病中,如血液系统恶性肿瘤、心血管疾病、糖尿病和自身免疫性疾病等,CH 已成为一种新的风险因素。未来,对驱动 CH 演变的机制进行表征对于开发预防和治疗方法至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical and Therapeutic Implications of Clonal Hematopoiesis.

Clonal hematopoiesis (CH) is an age-related process whereby hematopoietic stem and progenitor cells (HSPCs) acquire mutations that lead to a proliferative advantage and clonal expansion. The most commonly mutated genes are epigenetic regulators, DNA damage response genes, and splicing factors, which are essential to maintain functional HSPCs and are frequently involved in the development of hematologic malignancies. Established risk factors for CH, including age, prior cytotoxic therapy, and smoking, increase the risk of acquiring CH and/or may increase CH fitness. CH has emerged as a novel risk factor in many age-related diseases, such as hematologic malignancies, cardiovascular disease, diabetes, and autoimmune disorders, among others. Future characterization of the mechanisms driving CH evolution will be critical to develop preventative and therapeutic approaches.

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来源期刊
CiteScore
14.90
自引率
1.10%
发文量
29
期刊介绍: Since its inception in 2000, the Annual Review of Genomics and Human Genetics has been dedicated to showcasing significant developments in genomics as they pertain to human genetics and the human genome. The journal emphasizes genomic technology, genome structure and function, genetic modification, human variation and population genetics, human evolution, and various aspects of human genetic diseases, including individualized medicine.
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