新型 MFS 外排泵 SxtP 受 LysR 型转录激活因子 SxtR 的调控，参与了对磺胺甲噁唑/三甲氧苄啶（SXT）的敏感性和鲍曼不动杆菌的发病机制。

IF 4.1 2区医学 Q2 MICROBIOLOGY

Antimicrobial Agents and Chemotherapy Pub Date : 2024-10-08 Epub Date: 2024-08-28 DOI:10.1128/aac.00712-24

Marc Gaona, Jordi Corral, Susana Campoy, Jordi Barbé, María Pérez Varela, Jesús Aranda

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引用次数: 0

摘要

鲍曼不动杆菌（Acinetobacter baumannii）是一种臭名昭著的机会性病原体，是全球医疗相关感染的罪魁祸首。外排泵在介导抗菌药耐药性、运动性和毒力方面发挥着至关重要的作用。在本研究中，我们鉴定并描述了属于 MFS 超家族（主要促进剂超家族）的新型鲍曼不动杆菌外排泵 SxtP 及其相关激活剂 LysR 型转录调控因子（LTTR）SxtR，证明了它们在磺胺甲噁唑/三甲氧苄啶（又称共三唑或 SXT）耐药性、表面相关运动性和毒力方面的作用。

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The novel MFS efflux pump SxtP, regulated by the LysR-type transcriptional activator SxtR, is involved in the susceptibility to sulfamethoxazole/trimethoprim (SXT) and the pathogenesis of Acinetobacter baumannii.

Acinetobacter baumannii is a notorious opportunistic pathogen responsible for healthcare-associated infections worldwide. Efflux pumps play crucial roles in mediating antimicrobial resistance, motility, and virulence. In this study, we present the identification and characterization of the new A. baumannii efflux pump SxtP belonging to the MFS superfamily (major facilitator superfamily), along with its associated activator LysR-type transcriptional regulator (LTTR) SxtR, demonstrating their roles in sulfamethoxazole/trimethoprim (also known as co-trimoxazole or SXT) resistance, surface-associated motility and virulence.

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.