[内质网质量控制系统:治疗椎间盘变性的潜在靶点】。]

Q3 Medicine
生理学报 Pub Date : 2024-08-25
Yu Sun, En-Xu Liu, Zhao-Yong Li, Jia-Hao Duan, Fei Sun, Lei Yang, Shao-Feng Yang
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引用次数: 0

摘要

作为真核细胞中最大的细胞器,内质网(ER)在调节细胞内蛋白质折叠、翻译和组装方面发挥着至关重要的作用。ER中的多种质量控制机制确保了ER腔内蛋白质的准确修饰,从而维持钙平衡、氧化应激、细胞衰老和细胞凋亡。这些机制包括ER应激(ERS)、ER自噬(ER-phagy,ERPA)和ER相关降解(ERAD)。椎间盘变性(IDD)是一种与年龄有关的脊柱退行性疾病。虽然 IDD 的发病机制尚未完全阐明,但新的证据表明,ER 质量控制系统可能与 IDD 的进展有关。以往的研究主要集中于线粒体质量控制及其在疾病中的相关机制,而对ER质量控制系统的系统性总结却很有限。本文全面回顾了ER质控系统的分子机制,并研究了其与IDD的关联。此外,我们还总结了针对ER质控系统的潜在治疗策略,以减慢IDD的进展,为IDD的发病机制和再生修复策略提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Endoplasmic reticulum quality control system: a potential target for the treatment of intervertebral disc degeneration].

As the largest organelle in eukaryotic cells, the endoplasmic reticulum (ER) plays a crucial role in regulating intracellular protein folding, translation and assembly. Multiple quality control mechanisms in the ER ensure accurate modification of proteins in the ER lumen are accurately modified, thus maintaining calcium homeostasis, oxidative stress, cellular senescence and apoptosis. These mechanisms include ER stress (ERS), ER autophagy (ER-phagy, ERPA) and ER-associated degradation (ERAD). Intervertebral disc degeneration (IDD) is an age-related degenerative disease of the spine. Although the pathogenesis of IDD has not been fully elucidated, emerging evidence suggests that the ER quality control system may be involved in its progression. Previous studies have focused on mitochondrial quality control and its related mechanisms in diseases, with limited systematic summaries on the ER quality control system. In this paper, we comprehensively reviewed the molecular mechanisms of the ER quality control system and investigated its association with IDD. In addition, we summarized the potential therapeutic strategies targeting the ER quality control system to attenuate IDD progression, offering new insights into the pathogenesis and regenerative repair strategies of IDD.

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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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