放射性变色 OC-1 薄膜在光子、电子和质子束中的响应特性。

IF 3.2 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Medical physics Pub Date : 2024-08-26 DOI:10.1002/mp.17356
Qinghao Chen, Xiandong Zhao, Jufri Setianegara, Yao Hao, Tianyu Zhao, Tiezhi Zhang, Arash Darafsheh
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引用次数: 0

摘要

背景:放射性变色膜剂量计(RCF)具有高空间分辨率和组织等效特性,可方便地用于二维和小场剂量测定。OC-1 是最近推出的一种新型 RCF 剂量计。目的:研究 OC-1 RCF 对兆压临床 X 射线、电子和质子束以及小动物研究辐照装置中使用的千伏 X 射线束的响应:将 OC-1 RCF 切成 ∼4 × 4 cm2 的小块。使用不同的模式对 RCF 样品进行 0.5-120 Gy 范围内不同剂量水平的辐照:小动物辐射研究平台(SARRP)(220 kVp)、医用直线加速器(6 MV、10 MV、15 MV、6 MV FFF、10 MV FFF 光子束以及 6 MeV 和 20 MeV 电子束)和龙门式质子治疗同步循环加速器。为了研究分馏方案的依赖性,对一组胶片进行了相同剂量的分馏。在 200-600 MU/min 的范围内,向一组薄膜投放不同的剂量率,以研究剂量率的依赖性。使用平板扫描仪对辐照前和辐照后 48 小时的薄膜进行扫描。测量了每张薄膜的红、绿、蓝三色通道的净光密度(OD)。通过扫描八个不同方向的薄膜,研究了方向依赖性。为了研究薄膜响应的时间演变,使用 6 MV 光子束对薄膜样品进行了 10 Gy 和 50 Gy 的辐照,并在辐照后的一定时间间隔内进行扫描,最长可达 3 个月。使用光谱仪研究了薄膜在可见光范围内的光谱响应:在质子束的兆伏光子、电子和高原区,我们没有观察到对束流质量、剂量率和分馏方案的显著依赖。在千伏光束下,薄膜的净外径出现了不寻常的过度响应。我们观察到薄膜的响应与取向有关,呈正弦曲线趋势。薄膜的响应随时间呈双倍或三倍指数趋势增加。光谱吸收峰随剂量而蓝移:结论:OC-1 RCF 是可靠的剂量计,在 MV 范围内对光子和电子束(包括 FFF 束)没有明显的能量依赖性。与中压 X 射线束相比,它们在接受千伏 X 射线束照射时反应过度。扫描时必须注意保持胶片的方向。由于胶片的净外径会随着时间的推移而增长,因此在扫描校准胶片和测试胶片时必须使用相同的辐照后时间间隔。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Response characterization of radiochromic OC-1 films in photon, electron, and proton beams

Response characterization of radiochromic OC-1 films in photon, electron, and proton beams

Background

Radiochromic film (RCF) dosimeters with their high spatial resolution and tissue equivalent properties are conveniently used for two-dimensional and small-field dosimetry. OC-1 is a new model of RCF dosimeter that was commercially introduced recently. Due to its novelty there is a need to characterize its response in various radiation beam types.

Purpose

To study the response of OC-1 RCFs to megavoltage clinical x-ray, electron, and proton beams, as well as kilovoltage x-ray beams used in a small animal research irradiator.

Materials and methods

OC-1 RCFs were cut into ∼4 × 4 cm2 pieces. RCF samples were irradiated at various dose levels in the range 0.5–120 Gy using different modalities; a small animal radiation research platform (SARRP) (220 kVp), a medical linear accelerator (6 MV, 10 MV, 15 MV, 6 MV FFF, 10 MV FFF photon beams, as well as 6 and 20 MeV electron beams), and a gantry-mounted proton therapy synchrocyclotron. In order to study any dependency on the fractionation scheme, same dose was delivered at several fractions to a set of films. Different dose rates in the range 200–600 MU/min were delivered to a set of films to investigate any dose rate dependency. The films were scanned pre-irradiation and at 48 h post-irradiation using a flatbed scanner. The net optical density (OD) was measured for red, green, and blue color channel for each film. The orientation dependency was studied by scanning the films at eight different orientations. In order to study the temporal evolution of the response of the films, film samples were irradiated at 10 and 50 Gy using 6 MV photon beams and were scanned upon irradiation at certain time intervals up to 3 months. The spectral response of the films were studied over the visible range using a spectrometer.

Results

For megavoltage photon, electron, and plateau region of the proton beams, we did not observe a significant dependency on the beam quality, dose rate, and fractionation scheme. At the kV beam, an unusual over-response was observed in the films’ net OD. An orientation dependency in the response of the films with a sinusoidal trend was observed. The response of the films increased with time following a double or triple exponential trend. The spectral absorption peaks were blue-shifted with dose.

Conclusion

OC-1 RCFs were found to be reliable dosimeters with no significant energy dependency in MV range for photon and electron beams including the FFF beams. They over-respond when irradiated by kV x-ray beams compared to MV x-ray beams. Caution must be exercised to maintain the orientation of the films when scanning. Due to the temporal growth in the net OD of the films, same post-irradiation time interval must be used for scanning the calibration and test films.

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来源期刊
Medical physics
Medical physics 医学-核医学
CiteScore
6.80
自引率
15.80%
发文量
660
审稿时长
1.7 months
期刊介绍: Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.
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