肌肉疏松症:有关检测、进展和代谢变化以及治疗目标的最新进展。

IF 1.7 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Syeda Roohina Ali, Augustine T Nkembo, Srinivas M Tipparaju, Muhammad Ashraf, Wanling Xuan
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引用次数: 0

摘要

肌肉疏松症是一种以肌肉流失和功能障碍为特征的疾病,是一个全球性的健康问题,尤其是在老龄人口中。肌肉疏松症与肥胖、吞咽困难和虚弱等各种健康状况密切相关,这凸显了其复杂性。尽管代谢组学和其他用于早期检测和治疗的 omics 数据取得了最新进展,但肌肉疏松症的精确表征和诊断仍具有挑战性。在本综述中,我们概述了导致肌肉疏松症的复杂代谢机制,并特别强调了蛋白质、脂质、碳水化合物和骨代谢。综述强调了亮氨酸和其他氨基酸在促进肌肉蛋白质合成方面的重要性,并阐明了氨基酸代谢在维护肌肉健康方面的关键作用。此外,该综述还就脂质代谢对肌肉疏松症的影响提供了见解,重点是炎症和胰岛素抵抗的影响。综述还通过强调肌肉疏松症与骨代谢之间的相互作用,强调骨骼和肌肉健康之间的复杂关系。此外,综述还概述了诊断肌肉疏松症的各种治疗方法和潜在生物标志物。其中包括激素替代疗法和合成代谢类固醇等药物治疗策略,以及运动、营养和饮食改变等生活方式调整。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets.

Sarcopenia, a disorder marked by muscle loss and dysfunction, is a global health concern, particularly in aging populations. Sarcopenia is intricately related to various health conditions, including obesity, dysphagia, and frailty, which underscores the complexity. Despite recent advances in metabolomics and other omics data for early detection and treatment, the precise characterization and diagnosis of sarcopenia remains challenging. In the present review we provide an overview of the complex metabolic mechanisms that underlie sarcopenia, with particular emphasis on protein, lipid, carbohydrate, and bone metabolism. The review highlights the importance of leucine and other amino acids in promoting muscle protein synthesis and clarifies the critical role played by amino acid metabolism in preserving muscular health. In addition, the review provides insights regarding lipid metabolism on sarcopenia, with an emphasis on the effects of inflammation and insulin resistance. The development of sarcopenia is largely influenced by insulin resistance, especially with regard to glucose metabolism. Overall, the review emphasizes the complex relationship between bone and muscle health by highlighting the interaction between sarcopenia and bone metabolism. Furthermore, the review outlines various therapeutic approaches and potential biomarkers for diagnosing sarcopenia. These include pharmacological strategies such as hormone replacement therapy and anabolic steroids as well as lifestyle modifications such as exercise, nutrition, and dietary changes.

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来源期刊
CiteScore
4.00
自引率
4.80%
发文量
90
审稿时长
3-8 weeks
期刊介绍: Published since 1929, the Canadian Journal of Physiology and Pharmacology is a monthly journal that reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership. The journal periodically publishes a “Made In Canada” special section that features invited review articles from internationally recognized scientists who have received some of their training in Canada.
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