心肺康复对冠状病毒病-2019 后患者脑室-动脉耦合的影响

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
ACS Applied Electronic Materials Pub Date : 2024-09-01 Epub Date: 2024-09-03 DOI:10.1097/HCR.0000000000000885
Maria-Ioanna Gounaridi, Nektarios Souvaliotis, Angelos Vontetsianos, Nikolaos Chynkiamis, Stamatios Lampsas, Panagiotis Theofilis, Artemis Anastasiou, Athina Goliopoulou, Ioanna Tzima, Ourania Katsarou, Petros Bakakos, Manolis Vavouranakis, Nikolaos Koulouris, Gerasimos Siasos, Evangelos Oikonomou
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引用次数: 0

摘要

目的:冠状病毒病-2019(COVID-19)即使在疾病的急性期过后仍会影响心血管系统。心肺康复可改善COVID-19后的症状。本研究旨在评估急性 COVID-19 后心肺康复计划对动脉僵化、左心室功能和心室-动脉耦合(VAC)的影响:方法:48 名成年人在 COVID-19 恢复后 1 个月(T0)和 3 个月(T1)接受了检查,并按 1:1 随机分配参加或不参加为期 3 个月的康复计划。匹配的受试者作为非 COVID-19 组进行登记。动脉僵化通过颈动脉-股动脉脉搏波速度(PWV)进行评估。左心室(LV)收缩性能通过全纵向应变(GLS)进行评估。脉搏波速度/左心室纵向应变比被计算为 VAC 指数。测量高敏C反应蛋白(hs-CRP):结果:与非 COVID-19 患者相比,COVID-19 康复患者在 T0 时脉搏波速度受损(P= .001),VAC 降低(P= .001)。脉搏波速度(从 8.15 ± 1.37 米/秒降至 6.55 ± 0.98 米/秒,P 结论:COVID-19 患者的脉搏波速度和脉搏波速度均有所下降:对 COVID-19 患者进行为期 3 个月的康复训练可促进动脉僵化、左心室功能和 VAC 的恢复,凸显了康复训练对这类患者的有益机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Impact of Cardiopulmonary Rehabilitation on Ventriculoarterial Coupling in Post-Coronavirus Disease-2019 Patients.

Purpose: Coronavirus disease-2019 (COVID-19) affects the cardiovascular system even after the acute phase of the disease. Cardiopulmonary rehabilitation may improve post-COVID-19 symptoms. This study aims to evaluate the impact of a cardiopulmonary rehabilitation program after acute COVID-19 on arterial stiffness, left ventricular function, and ventriculoarterial coupling (VAC).

Methods: Forty-eight adults were examined 1 (T0) and 3-mo (T1) following recovery from COVID-19 and randomized 1:1 to participate or not in a 3-mo rehabilitation program. Matched subjects were enrolled as a non-COVID-19 group. Arterial stiffness was evaluated by carotid-femoral pulse wave velocity (PWV). Left ventricular (LV) systolic performance was evaluated with global longitudinal strain (GLS). The PWV/LV-GLS ratio was calculated as an index of VAC. High-sensitivity C reactive protein (hs-CRP) was measured.

Results: At T0, convalescent patients with COVID-19 had impaired PWV ( P = .001) and reduced VAC ( P = .001) compared to non-COVID-19 subjects. PWV (8.15 ± 1.37 to 6.55 ± 0.98 m/sec, P < .001) and LV-GLS (-19.67 ± 1.98 to -21.3 ± 1.93%, P < .001) improved only in convalescent patients with COVID-19 undergoing rehabilitation. Similarly, VAC was only improved in the rehabilitation group (-0.42 ± 0.11 to -0.31 ± 0.06 m · sec -1  ·% -1 , P < .001). A significant improvement in VO 2max was noted after rehabilitation (15.70 [13.05, 21.45] to 18.30 [13.95, 23.75] ml · kg -1  · min -1 , P = .01). Finally, hs-CRP was improved in both groups with a significantly greater improvement in the rehabilitation group.

Conclusion: A 3-mo rehabilitation program in convalesced patients with COVID-19 enhances the recovery of arterial stiffness, left ventricular function, and VAC, highlighting the beneficial mechanisms of rehabilitation in this patient population.

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CiteScore
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