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引用次数: 0
摘要
背景：由于粪肠球菌（E. faecalis）出现越来越多的抗生素耐药性，它被认为是潜在的机会性病原体，可在全球范围内引起各种医疗相关疾病和危及生命的疾病：本荟萃分析旨在根据时间、地区、抗菌药物敏感性检测（AST）和感染源来评估临床粪肠球菌分离物的加权集合耐药率：我们在 PubMed、Scopus 和 Web of Science（2022 年 11 月 30 日）中检索了相关研究。所有统计分析均使用 R 统计软件包进行：结果：分析涵盖了在 28 个国家进行的 74 项研究。根据元回归结果，氯霉素、磷霉素、亚胺培南、利奈唑胺、米诺环素、诺氟沙星、奎奴普汀-达福普汀和四环素的耐药率随着时间的推移而增加。分析显示，氨苄西林、氯霉素、红霉素、庆大霉素、青霉素、利福平、替考拉宁、四环素和万古霉素的抗生素耐药率在不同国家之间存在显著的统计学差异：全球范围内，耐药性粪肠球菌菌株的流行率随着时间的推移呈上升趋势。达托霉素和替加环素是治疗临床粪肠球菌感染的有效药物。考虑到欧洲大陆和澳大利亚的抗生素耐药性流行率较低，建议利用其预防策略，以便在其他耐药性流行率较高的地方取得有效的治疗效果。
Global status of antimicrobial resistance in clinical Enterococcus faecalis isolates: systematic review and meta-analysis.
Background: Due to the increasing emergence of antibiotic resistance in Enterococcus faecalis (E. faecalis), it indicated as potentially opportunistic pathogen causing various healthcare-associated and life-threatening diseases around the world.
Objective: The aim of this meta-analysis was to evaluate the weighted pooled resistance rates in clinical E. faecalis isolates based on over time, areas, antimicrobial susceptibility testing (AST), and infection source.
Methods: We searched the studies in PubMed, Scopus, and Web of Science (November 30, 2022). All statistical analyses were carried out using the statistical package R.
Results: The analysis encompassed a total of 74 studies conducted in 28 countries. According to the meta-regression, the chloramphenicol, fosfomycin, imipenem, linezolid, minocycline, norfloxacin, quinupristin-dalfopristin, and tetracycline resistance rate increased over time. Analysis revealed statistically significant differences in antibiotic resistance rates for ampicillin, chloramphenicol, erythromycin, gentamicin, penicillin, rifampicin, teicoplanin, tetracycline, and vancomycin across various countries.
Conclusions: Globally, the prevalence of drug resistant E. faecalis strains are on the increase over time. Daptomycin and tigecycline can be an effective agent for the treatment of clinical E. faecalis infections. Considering the low prevalence of antibiotic resistance in continents of Europe and Australia, it is suggested to take advantage of their preventive strategies in order to obtain efficient results in other places with high prevalence of resistance.
期刊介绍：
Annals of Clinical Microbiology and Antimicrobials considers good quality, novel and international research of more than regional relevance. Research must include epidemiological and/or clinical information about isolates, and the journal covers the clinical microbiology of bacteria, viruses and fungi, as well as antimicrobial treatment of infectious diseases.
Annals of Clinical Microbiology and Antimicrobials is an open access, peer-reviewed journal focusing on information concerning clinical microbiology, infectious diseases and antimicrobials. The management of infectious disease is dependent on correct diagnosis and appropriate antimicrobial treatment, and with this in mind, the journal aims to improve the communication between laboratory and clinical science in the field of clinical microbiology and antimicrobial treatment. Furthermore, the journal has no restrictions on space or access; this ensures that the journal can reach the widest possible audience.
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