Dante P.I. Capaldi , Jen-Yeu Wang , Lianli Liu , Vipul R. Sheth , Elizabeth A. Kidd , Dimitre H. Hristov
{"title":"同时接受化疗和放疗的局部晚期宫颈癌患者体内体素内非相干运动磁共振成像和正电子发射断层扫描的参数反应图谱","authors":"Dante P.I. Capaldi , Jen-Yeu Wang , Lianli Liu , Vipul R. Sheth , Elizabeth A. Kidd , Dimitre H. Hristov","doi":"10.1016/j.phro.2024.100630","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and Purpose</h3><p>Intravoxel-incoherent-motion (IVIM) magnetic-resonance-imaging (MRI) and positron-emission-tomography (PET) have been investigated independently but not voxel-wise to evaluate tumor microenvironment in cervical carcinoma patients. Whether regionally combined information of IVIM and PET offers additional predictive benefit over each modality independently has not been explored. Here, we investigated parametric-response-mapping (PRM) of co-registered PET and IVIM in cervical cancer patients to identify sub-volumes that may predict tumor shrinkage to concurrent-chemoradiation-therapy (CCRT).</p></div><div><h3>Materials and Methods</h3><p>Twenty cervical cancer patients (age: 63[41–85]) were retrospectively evaluated. Diffusion-weighted-images (DWIs) were acquired on 3.0 T MRIs using a free-breathing single-shot-spin echo-planar-imaging (EPI) sequence. Pre- and on-treatment (∼after four-weeks of CCRT) MRI and pre-treatment FDG-PET/CT were acquired. IVIM model-fitting on the DWIs was performed using a Bayesian-fitting simplified two-compartment model. Three-dimensional rigidly-registered maps of PET/CT standardized-uptake-value (SUV) and IVIM diffusion-coefficient (<em>D</em>) and perfusion-fraction (<em>f</em>) were generated. Population-means of PET-SUV, IVIM-<em>D</em> and IVIM-<em>f</em> from pre-treatment-scans were calculated and used to generate PRM via a voxel-wise joint-histogram-analysis to classify voxels as high/low metabolic-activity and with high/low (hi/lo) cellular-density. Similar PRM maps were generated for SUV and <em>f</em>.</p></div><div><h3>Results</h3><p>Tumor-volume (p < 0.001) significantly decreased, while IVIM-<em>f</em> (p = 0.002) and IVIM-<em>D</em> (p = 0.03) significantly increased on-treatment. Pre-treatment tumor-volume (r = -0.45,p = 0.04) and PRM-SUV<sup>hi</sup><em>D</em><sup>lo</sup> (r = -0.65,p = 0.002) negatively correlated with ΔGTV, while pre-treatment IVIM-<em>D</em> (r = 0.64,p = 0.002), PRM-SUV<sup>lo</sup><em>f</em><sup>hi</sup> (r = 0.52,p = 0.02), and PRM-SUV<sup>lo</sup><em>D</em><sup>hi</sup> (r = 0.74,p < 0.001) positively correlated with ΔGTV.</p></div><div><h3>Conclusion</h3><p>IVIM and PET was performed on cervical cancer patients undergoing CCRT and we observed that both IVIM-<em>f</em> and IVIM-<em>D</em> increased during treatment. Additionally, PRM was applied, and sub-volumes were identified that were related to ΔGTV.</p></div>","PeriodicalId":36850,"journal":{"name":"Physics and Imaging in Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405631624001003/pdfft?md5=9ebf67427560b68162bc21c29c446c95&pid=1-s2.0-S2405631624001003-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Parametric response mapping of co-registered intravoxel incoherent motion magnetic resonance imaging and positron emission tomography in locally advanced cervical cancer undergoing concurrent chemoradiation therapy\",\"authors\":\"Dante P.I. Capaldi , Jen-Yeu Wang , Lianli Liu , Vipul R. Sheth , Elizabeth A. Kidd , Dimitre H. Hristov\",\"doi\":\"10.1016/j.phro.2024.100630\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and Purpose</h3><p>Intravoxel-incoherent-motion (IVIM) magnetic-resonance-imaging (MRI) and positron-emission-tomography (PET) have been investigated independently but not voxel-wise to evaluate tumor microenvironment in cervical carcinoma patients. Whether regionally combined information of IVIM and PET offers additional predictive benefit over each modality independently has not been explored. Here, we investigated parametric-response-mapping (PRM) of co-registered PET and IVIM in cervical cancer patients to identify sub-volumes that may predict tumor shrinkage to concurrent-chemoradiation-therapy (CCRT).</p></div><div><h3>Materials and Methods</h3><p>Twenty cervical cancer patients (age: 63[41–85]) were retrospectively evaluated. Diffusion-weighted-images (DWIs) were acquired on 3.0 T MRIs using a free-breathing single-shot-spin echo-planar-imaging (EPI) sequence. Pre- and on-treatment (∼after four-weeks of CCRT) MRI and pre-treatment FDG-PET/CT were acquired. IVIM model-fitting on the DWIs was performed using a Bayesian-fitting simplified two-compartment model. Three-dimensional rigidly-registered maps of PET/CT standardized-uptake-value (SUV) and IVIM diffusion-coefficient (<em>D</em>) and perfusion-fraction (<em>f</em>) were generated. Population-means of PET-SUV, IVIM-<em>D</em> and IVIM-<em>f</em> from pre-treatment-scans were calculated and used to generate PRM via a voxel-wise joint-histogram-analysis to classify voxels as high/low metabolic-activity and with high/low (hi/lo) cellular-density. Similar PRM maps were generated for SUV and <em>f</em>.</p></div><div><h3>Results</h3><p>Tumor-volume (p < 0.001) significantly decreased, while IVIM-<em>f</em> (p = 0.002) and IVIM-<em>D</em> (p = 0.03) significantly increased on-treatment. Pre-treatment tumor-volume (r = -0.45,p = 0.04) and PRM-SUV<sup>hi</sup><em>D</em><sup>lo</sup> (r = -0.65,p = 0.002) negatively correlated with ΔGTV, while pre-treatment IVIM-<em>D</em> (r = 0.64,p = 0.002), PRM-SUV<sup>lo</sup><em>f</em><sup>hi</sup> (r = 0.52,p = 0.02), and PRM-SUV<sup>lo</sup><em>D</em><sup>hi</sup> (r = 0.74,p < 0.001) positively correlated with ΔGTV.</p></div><div><h3>Conclusion</h3><p>IVIM and PET was performed on cervical cancer patients undergoing CCRT and we observed that both IVIM-<em>f</em> and IVIM-<em>D</em> increased during treatment. Additionally, PRM was applied, and sub-volumes were identified that were related to ΔGTV.</p></div>\",\"PeriodicalId\":36850,\"journal\":{\"name\":\"Physics and Imaging in Radiation Oncology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2405631624001003/pdfft?md5=9ebf67427560b68162bc21c29c446c95&pid=1-s2.0-S2405631624001003-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physics and Imaging in Radiation Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405631624001003\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics and Imaging in Radiation Oncology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405631624001003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Parametric response mapping of co-registered intravoxel incoherent motion magnetic resonance imaging and positron emission tomography in locally advanced cervical cancer undergoing concurrent chemoradiation therapy
Background and Purpose
Intravoxel-incoherent-motion (IVIM) magnetic-resonance-imaging (MRI) and positron-emission-tomography (PET) have been investigated independently but not voxel-wise to evaluate tumor microenvironment in cervical carcinoma patients. Whether regionally combined information of IVIM and PET offers additional predictive benefit over each modality independently has not been explored. Here, we investigated parametric-response-mapping (PRM) of co-registered PET and IVIM in cervical cancer patients to identify sub-volumes that may predict tumor shrinkage to concurrent-chemoradiation-therapy (CCRT).
Materials and Methods
Twenty cervical cancer patients (age: 63[41–85]) were retrospectively evaluated. Diffusion-weighted-images (DWIs) were acquired on 3.0 T MRIs using a free-breathing single-shot-spin echo-planar-imaging (EPI) sequence. Pre- and on-treatment (∼after four-weeks of CCRT) MRI and pre-treatment FDG-PET/CT were acquired. IVIM model-fitting on the DWIs was performed using a Bayesian-fitting simplified two-compartment model. Three-dimensional rigidly-registered maps of PET/CT standardized-uptake-value (SUV) and IVIM diffusion-coefficient (D) and perfusion-fraction (f) were generated. Population-means of PET-SUV, IVIM-D and IVIM-f from pre-treatment-scans were calculated and used to generate PRM via a voxel-wise joint-histogram-analysis to classify voxels as high/low metabolic-activity and with high/low (hi/lo) cellular-density. Similar PRM maps were generated for SUV and f.
Results
Tumor-volume (p < 0.001) significantly decreased, while IVIM-f (p = 0.002) and IVIM-D (p = 0.03) significantly increased on-treatment. Pre-treatment tumor-volume (r = -0.45,p = 0.04) and PRM-SUVhiDlo (r = -0.65,p = 0.002) negatively correlated with ΔGTV, while pre-treatment IVIM-D (r = 0.64,p = 0.002), PRM-SUVlofhi (r = 0.52,p = 0.02), and PRM-SUVloDhi (r = 0.74,p < 0.001) positively correlated with ΔGTV.
Conclusion
IVIM and PET was performed on cervical cancer patients undergoing CCRT and we observed that both IVIM-f and IVIM-D increased during treatment. Additionally, PRM was applied, and sub-volumes were identified that were related to ΔGTV.
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