CD36+ 促炎巨噬细胞与甲状腺乳头状癌中的 ZCCHC12+ 肿瘤细胞相互作用,促进肿瘤进展和复发。

IF 8.1 1区 医学 Q1 IMMUNOLOGY
Xin Zhang, Limei Guo, Wenyu Tian, Ying Yang, Yue Yin, Yaruo Qiu, Weixuan Wang, Yang Li, Guangze Zhang, Xuyang Zhao, Guangxi Wang, Zhiqiang Lin, Meng Yang, Wei Zhao, Dan Lu
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引用次数: 0

摘要

局部复发和远处转移会对甲状腺乳头状癌(PTC)患者的生存和生活质量产生负面影响。因此,确定 PTC 的潜在生物标志物和治疗靶点在临床上至关重要。在这项研究中,我们进行了一项多组学分析,发现了PTC肿瘤微环境中的CD36+促炎巨噬细胞亚群。CD36+巨噬细胞被招募到恶性肿瘤前区域与PTC的不良预后密切相关,肿瘤浸润CD36+巨噬细胞的存在被确定为复发的风险因素。CD36+ 巨噬细胞与代谢活跃的 ZCCHC12+ 肿瘤细胞相互作用。通过分泌 SPP1,CD36+ 巨噬细胞激活了 PI3K-AKT 信号通路,从而促进了癌细胞的增殖。碘代谢失调与巨噬细胞获得促炎表型密切相关。补碘可抑制促炎信号的激活,并通过增强 DUSP2 的表达阻碍 CD36+ 巨噬细胞的发展。总之,我们的研究结果揭示了 CD36+ 巨噬细胞和 ZCCHC12+ 肿瘤细胞之间错综复杂的相互影响,为 PTC 的治疗和预后提供了有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CD36+ Proinflammatory Macrophages Interact with ZCCHC12+ Tumor Cells in Papillary Thyroid Cancer Promoting Tumor Progression and Recurrence.

Local recurrence and distal metastasis negatively impact the survival and quality of life in patients with papillary thyroid cancer (PTC). Therefore, identifying potential biomarkers and therapeutic targets for PTC is clinically crucial. In this study, we performed a multiomics analysis that identified a subset of CD36+ proinflammatory macrophages within the tumor microenvironment of PTC. The recruitment of CD36+ macrophages to premalignant regions strongly correlated with unfavorable outcomes in PTC, and the presence of tumor-infiltrating CD36+ macrophages was determined to be a risk factor for recurrence. The CD36+ macrophages exhibited interactions with metabolically active ZCCHC12+ tumor cells. By secreting SPP1, the CD36+ macrophages activated the PI3K-AKT signaling pathway, thereby promoting proliferation of the cancer cells. Dysregulation of iodine metabolism was closely related to the acquisition of the pro-inflammatory phenotype in macrophages. Iodine supplementation inhibited the activation of proinflammatory signaling and impeded the development of CD36+ macrophages by enhancing DUSP2 expression. Overall, our findings shed light on the intricate cross-talk between CD36+ macrophages and ZCCHC12+ tumor cells, providing valuable insights for the treatment and prognosis of PTC.

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来源期刊
Cancer immunology research
Cancer immunology research ONCOLOGY-IMMUNOLOGY
CiteScore
15.60
自引率
1.00%
发文量
260
期刊介绍: Cancer Immunology Research publishes exceptional original articles showcasing significant breakthroughs across the spectrum of cancer immunology. From fundamental inquiries into host-tumor interactions to developmental therapeutics, early translational studies, and comprehensive analyses of late-stage clinical trials, the journal provides a comprehensive view of the discipline. In addition to original research, the journal features reviews and opinion pieces of broad significance, fostering cross-disciplinary collaboration within the cancer research community. Serving as a premier resource for immunology knowledge in cancer research, the journal drives deeper insights into the host-tumor relationship, potent cancer treatments, and enhanced clinical outcomes. Key areas of interest include endogenous antitumor immunity, tumor-promoting inflammation, cancer antigens, vaccines, antibodies, cellular therapy, cytokines, immune regulation, immune suppression, immunomodulatory effects of cancer treatment, emerging technologies, and insightful clinical investigations with immunological implications.
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