比较射频与聚焦超声苍白球切开术治疗帕金森病的系统性综述。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2024-08-22 DOI:10.1159/000539911

Jennifer A Guidera, Sravani Kondapavulur, Doris D Wang

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引用次数: 0

摘要

简介聚焦超声（FUS）苍白球切开术是治疗帕金森病（PD）的一种前景广阔的新疗法。与射频（RF）苍白球切开术相比，聚焦超声苍白球切开术的疗效、运动结果和副作用尚不清楚：我们对 PD 患者的 FUS 苍白球切开术与射频苍白球切开术的疗效和副作用进行了系统回顾：结果：在4份RF报告和1份FUS报告中，RF与FUS苍白球切开术后的对侧UPDRS III评分无显著差异。在18份RF报告和2份FUS报告中，RF苍白球切开术的平均失败率为14%，而FUS苍白球切开术的平均失败率为24%。在25份RF和3份FUS报告中，RF苍白球切除术后认知障碍的发生率明显更高（p = 0.004）：目前，有限的数据和结果报告的异质性给 FUS 和 RF 苍白球切开术疗效和安全性的比较带来了挑战。现有证据表明，与射频苍白球切除术相比，FUS苍白球切除术的疗效大致相似，认知功能障碍的风险较低。在未来的研究中，对切除后的结果进行标准化报告将提高研究的有效性，并排除这些结果的潜在混杂因素。

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A Systematic Review Comparing Radiofrequency versus Focused Ultrasound Pallidotomy in the Treatment of Parkinson's Disease.

Introduction: Focused ultrasound (FUS) pallidotomy is a promising new therapy for Parkinson's disease (PD). The efficacy, motor outcomes, and side effects of FUS pallidotomy compared to radiofrequency (RF) pallidotomy are unknown.

Methods: We performed a systematic review of the outcomes and side effect profiles of FUS versus RF pallidotomy in patients with PD.

Results: Across four RF reports and one FUS report, putative contralateral UPDRS III scores were not significantly different following RF versus FUS pallidotomy. Across 18 RF and 2 FUS reports, the mean failure rate was 14% following RF pallidotomy versus 24% following FUS pallidotomy. Across 25 RF and 3 FUS reports, cognitive deficit was significantly more prevalent following RF pallidotomy (p = 0.004).

Conclusion: At present, limited data and heterogeneity in outcome reporting challenges comparisons of FUS and RF pallidotomy efficacy and safety. Available evidence suggests FUS pallidotomy may have broadly similar efficacy and a lower risk of cognitive impairment relative to RF pallidotomy. Standardized reporting of post-lesion outcomes in future studies would improve power and rule out potential confounders of these results.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.