合理设计自组装超短肽,用于形状和尺寸可调的金属纳米结构合成。

IF 1.8 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Urawadee Rajchakit, Hugh Douglas Glossop, Kelvin Wang, Jun Lu, Vijayalekshmi Sarojini
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引用次数: 0

摘要

肽具有独特的生物活性、生物功能性和生物兼容性,因此作为设计纳米复合水凝胶的平台引起了人们的极大兴趣。此前,我们曾报道过一个肽家族,它们通过自组装形成稳定的三维水凝胶网络,显示出强大的抗菌活性。在本文中,我们报告了使用这些水凝胶序列及其类似物作为稳定剂和生长控制剂合成不同大小和形状的各向异性金纳米粒子(AuNPs)的情况。其中,HG2.81-AuNPs 得到了空心球形纳米粒子,而 TOH_1N-AuNPs 和 PentaOH-AuNPs 在各自的水凝胶网络中则观察到了六角形纳米粒子。PentaOH-AuNPs 水凝胶对金黄色葡萄球菌和铜绿假单胞菌 ATCC 27853 具有很高的抗菌效力,细胞毒性可忽略不计。另一方面,TOH_1N-AuNPs 没有显示出抗菌活性和细胞毒性,这表明了这些肽的多功能性。这项研究为进一步开发这些材料的应用(如组织培养技术和伤口敷料材料)提供了依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Rational design of self-assembling ultrashort peptides for the shape- and size-tunable synthesis of metal nanostructures.

Rational design of self-assembling ultrashort peptides for the shape- and size-tunable synthesis of metal nanostructures.

Peptides have attracted great interest as platforms for the design of nanocomposite hydrogels due to their distinct bioactivity, biofunctionality and biocompatibility. Previously, we have reported on a family of peptides that self-assembled to form stabilised three-dimensional hydrogel networks, displaying potent antimicrobial activity. In this paper, we report on the use of these hydrogelator sequences and their analogues as stabilisers and growth controllers to synthesise anisotropic gold nanoparticles (AuNPs) of different sizes and shapes. In particular, hollow spherical nanoparticles were obtained for HG2.81-AuNPs, whereas hexagonal nanoparticles were observed for TOH_1N-AuNPs and PentaOH-AuNPs in their respective hydrogel networks. The PentaOH-AuNPs' hydrogel exhibited excellent results with high antimicrobial potency against Staphylococcus aureus and Pseudomonas aeruginosa ATCC 27853 and negligible cytotoxicity. On the other hand, TOH_1N-AuNPs showed no antibacterial activity and no cytotoxicity, demonstrating the versatility of these peptides. This work gives credence towards the development of these materials towards further applications such as in tissue culture technology and wound dressing materials.

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来源期刊
Journal of Peptide Science
Journal of Peptide Science 生物-分析化学
CiteScore
3.40
自引率
4.80%
发文量
83
审稿时长
1.7 months
期刊介绍: The official Journal of the European Peptide Society EPS The Journal of Peptide Science is a cooperative venture of John Wiley & Sons, Ltd and the European Peptide Society, undertaken for the advancement of international peptide science by the publication of original research results and reviews. The Journal of Peptide Science publishes three types of articles: Research Articles, Rapid Communications and Reviews. The scope of the Journal embraces the whole range of peptide chemistry and biology: the isolation, characterisation, synthesis properties (chemical, physical, conformational, pharmacological, endocrine and immunological) and applications of natural peptides; studies of their analogues, including peptidomimetics; peptide antibiotics and other peptide-derived complex natural products; peptide and peptide-related drug design and development; peptide materials and nanomaterials science; combinatorial peptide research; the chemical synthesis of proteins; and methodological advances in all these areas. The spectrum of interests is well illustrated by the published proceedings of the regular international Symposia of the European, American, Japanese, Australian, Chinese and Indian Peptide Societies.
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