评估接受抗 CGRP 单克隆抗体治疗的偏头痛患者横断面队列一年内的骨矿物质密度。

IF 7.4 2区 医学 Q1 CLINICAL NEUROLOGY
CNS drugs Pub Date : 2024-10-01 Epub Date: 2024-08-22 DOI:10.1007/s40263-024-01104-0
Davide Para, Chiara Camponovo, Gianna Carla Riccitelli, Giulia Mallucci, Paolo Maino, Camilla Mondini Trissino da Lodi, Demurtas Saudina, Pierpaolo Trimboli, Claudio Gobbi, Chiara Zecca
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引用次数: 0

摘要

背景:降钙素基因相关肽(CGRP)与偏头痛有关,它也具有骨质同化特性,这导致靶向CGRP的单克隆抗体(抗CGRPs)可能会增加骨密度异常的风险:本研究旨在探讨接受抗CGRPs治疗的偏头痛患者队列中的骨矿物质密度异常情况:这是一项单中心、横断面队列研究,研究对象包括在接受抗CGRP治疗期间接受骨密度测量评估的偏头痛患者。我们评估了骨质疏松症或骨质疏松症(OSTEO+状态)的频率,骨质疏松症或骨质疏松症(OSTEO+状态)的定义是骨矿密度T-score为-1至-2.5:评估了 51 名患者(43 名女性,平均年龄为 46 ± 13.9 岁)的数据。抗 CGRP 治疗的平均持续时间为 15.7(±11.8)个月。27 名患者(53%)为 OSTEO+(n = 22 例骨质疏松症;n = 5 例骨质疏松症)。在最终模型中,绝经[几率比 11.641(95% 置信区间 1.486-91.197),p = 0.019]和服用抗癫痫药物[几率比 12.825(95% 置信区间 1.162-141.569),p = 0.037]与 OSTEO+ 状态相关:在我们的偏头痛患者队列中,没有发现抗CGRP治疗持续时间与骨矿物质密度异常风险增加之间存在关联的证据。然而,这些研究结果只是初步的,还需要更大规模的队列和更长时间的随访来验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of Bone Mineral Density Over 1 Year in a Cross-Sectional Cohort of Migraine Patients Receiving Anti-CGRP Monoclonal Antibodies.

Background: Calcitonin gene-related peptide (CGRP), implicated in migraine pain, also possesses bone anabolic properties, which leads to the possibility that monoclonal antibodies targeting CGRP (anti-CGRPs) might increase the risk of bone density abnormalities.

Objective: The objective of this study was to explore bone mineral density abnormalities in a cohort of migraine patients treated with anti-CGRPs.

Methods: This was a single-center, cross-sectional, cohort study including migraine patients who underwent a densitometry assessment during anti-CGRP treatment. We assessed the frequency of osteopenia or osteoporosis (OSTEO+ status), defined as a bone mineral density T-score of -1 to -2.5, and <-2.5 standard deviations from the young female adult mean, respectively. Additionally, the association of OSTEO+ status with anti-CGRP treatment duration and primary osteoporosis' risk factors was investigated using logistic regression models.

Results: Data from 51 patients (43 female, mean age 46 ± 13.9 years) were evaluated. The mean duration of anti-CGRP treatment was 15.7 (±11.8) months. Twenty-seven patients (53%) were OSTEO+ (n = 22 osteopenia; n = 5 osteoporosis). In the final model, menopause [odds ratio 11.641 (95% confidence interval 1.486-91.197), p = 0.019] and anti-seizure drug use [odds ratio 12.825 (95% confidence interval 1.162-141.569), p = 0.037] were associated with OSTEO+ status.

Conclusions: In our cohort of migraine patients, no evidence of an association between anti-CGRP treatment duration and an increasing risk of bone mineral density abnormalities was found. However, these findings are preliminary and necessitate further longitudinal research with larger cohorts and extended follow-up to be validated.

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来源期刊
CNS drugs
CNS drugs 医学-精神病学
CiteScore
12.00
自引率
3.30%
发文量
82
审稿时长
6-12 weeks
期刊介绍: CNS Drugs promotes rational pharmacotherapy within the disciplines of clinical psychiatry and neurology. The Journal includes: - Overviews of contentious or emerging issues. - Comprehensive narrative reviews that provide an authoritative source of information on pharmacological approaches to managing neurological and psychiatric illnesses. - Systematic reviews that collate empirical evidence to answer a specific research question, using explicit, systematic methods as outlined by the PRISMA statement. - Adis Drug Reviews of the properties and place in therapy of both newer and established drugs in neurology and psychiatry. - Original research articles reporting the results of well-designed studies with a strong link to clinical practice, such as clinical pharmacodynamic and pharmacokinetic studies, clinical trials, meta-analyses, outcomes research, and pharmacoeconomic and pharmacoepidemiological studies. Additional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in CNS Drugs may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances.
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