利用 AutoMCS Navigator 绘制自噬相关膜接触点蛋白和复合物图。

Autophagy Pub Date : 2024-11-01 Epub Date: 2024-08-27 DOI:10.1080/15548627.2024.2394291
Tianyuan Liu, Xianrun Pan, Liping Ren, Xiucai Ye, Kai Zheng, Yang Zhang
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引用次数: 0

摘要

在真核细胞中,膜接触点(MCSs)通过使细胞器的膜在不融合的情况下相互靠近,介导细胞器之间的相互作用和交流。这些位点在细胞内运输、信号转导和细胞器功能调控中发挥着至关重要的作用。在最近的一项研究中,我们从出版物中汇编了MCS蛋白和复合物的数据,创建了MCSdb数据库。在数据编译过程中,我们发现许多 MCSs、其相关蛋白和复合物与大自噬/自噬高度相关。为了阐明 MCS 在自噬中的作用,我们重新组织了 MCSdb 中与自噬相关的 MCS 蛋白和复合物,创建了一个名为 AutoMCS 导航器的数据地图。该地图的当前版本包括 30 个复合物和 84 个蛋白质,涵盖 13 种不同的 MCS 和 7 个物种。同时,我们在 MCSdb 网站上为 AutoMCS 导航仪嵌入了一个专用网页。该网页提供了一个精心设计的可视化指南,分层显示参与自噬的 MCS 蛋白和复合物。总之,我们的研究开发了一种用户友好型可视化地图,用于查询、浏览和可视化自噬相关 MCS 蛋白和复合物的详细信息。该工具为研究人员了解自噬相关 MCS 的结构、组装、功能以及相关疾病的治疗策略提供了便利。AutoMCS Navigator 可在 https://cellknowledge.com.cn/mcsdb/autophagy.html 免费获取。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mapping autophagy-related membrane contact site proteins and complexes with AutoMCS Navigator.

In eukaryotic cells, membrane contact sites (MCSs) mediate interactions and communication between organelles by bringing their membranes into close proximity without fusion. These sites play crucial roles in intracellular transport, signal transduction, and the regulation of organelle functions. In a recent study, we compiled data on MCS proteins and complexes from publications to create the MCSdb database. During data compilation, we discovered that many MCSs, their associated proteins, and complexes are highly relevant to macroautophagy/autophagy. To elucidate the role of MCSs in autophagy, we reorganized the autophagy-related MCS proteins and complexes from MCSdb, creating a data map called AutoMCS Navigator. The current version of this map includes 30 complexes and 84 proteins, covering 13 different MCSs and 7 species. Meanwhile, we embedded a dedicated webpage for AutoMCS Navigator on the MCSdb website. This webpage features an orchestrated visual guide that hierarchically displays MCS proteins and complexes involved in autophagy. In summary, our research has developed a user-friendly visual map for querying, browsing, and visualizing detailed information on autophagy-related MCS proteins and complexes. This tool offers researchers easy access to understand autophagy-related MCS structure, assembly, functions, and therapeutic strategies for related diseases. AutoMCS Navigator is freely available at https://cellknowledge.com.cn/mcsdb/autophagy.html.

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