肝移植治疗小儿遗传性和代谢性疾病。

IF 4.7 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Liver Transplantation Pub Date : 2025-06-01 Epub Date: 2024-08-23 DOI:10.1097/LVT.0000000000000454

Sara Hassan, Ahmad Anouti, Queenie K G Tan, Kirk Wangensteen, Amal Aqul

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引用次数: 0

摘要

小儿遗传性和代谢性肝病包括多种病症，是继胆道闭锁之后第二大最常见的肝移植适应症。决定是否进行移植可能具有挑战性，需要考虑多种因素，包括肝脏受累、肝外表现和移植后的预期结果。本综述探讨了儿科遗传性和代谢性肝病、其病理生理学、临床表现以及肝移植的作用。

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Liver transplantation for pediatric genetic and metabolic disorders.

Pediatric genetic and metabolic liver diseases comprise a broad spectrum of conditions and represent the second most common indication for liver transplantation following biliary atresia. The decision to transplant can be challenging and requires consideration of several factors, including hepatic involvement, extrahepatic manifestations, and anticipated posttransplant outcomes. This review examines pediatric genetic and metabolic liver diseases, their pathophysiology, clinical presentation, and the role of liver transplantation.

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来源期刊

Liver Transplantation 医学-外科

CiteScore

7.40

自引率

6.50%

发文量

254

审稿时长

3-8 weeks

期刊介绍： Since the first application of liver transplantation in a clinical situation was reported more than twenty years ago, there has been a great deal of growth in this field and more is anticipated. As an official publication of the AASLD, Liver Transplantation delivers current, peer-reviewed articles on liver transplantation, liver surgery, and chronic liver disease — the information necessary to keep abreast of this evolving specialty.