探索肺缺血再灌注损伤的研究进展和演变趋势:从1979年到2023年的文献计量分析。

IF 5.2 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
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引用次数: 0

摘要

背景:肺缺血再灌注损伤(LIRI)在各种临床情况下都是一项重大挑战。尽管对肺缺血再灌注损伤的发病机制和潜在治疗方法进行了广泛的研究,但文献计量分析却明显缺乏:我们通过在科学网(Web of Science)上以 "肺 "和 "再灌注损伤 "为主题词进行的两次搜索,总结了从 1979 年到 2023 年有关 LIRI 的研究成果。文献计量学软件根据国家、作者和关键词对收集到的数据进行了分析和可视化。为了探究肺再灌注损伤研究领域的热点,还进一步添加了关键词 "程序性细胞死亡":对 1648 篇研究文章的初步分析表明,共有 40 个国家和 7031 名研究人员发表了相关文章,其中美国是 LIRI 研究领域成果最多的国家。关键词分析显示,LIRI 研究的重点已从肺移植、原发性移植物功能障碍、炎症、氧化应激和体外肺灌注逐步过渡到细胞死亡。随后,212 篇论文专门讨论了 LIRI 中的程序性细胞死亡(PCD),明确了 LIRI 领域的最新热点:结论:随着国际合作的加强和研究规模的扩大,LIRI 研究主要集中在 LIRI 的发病机制和潜在的治疗干预方面。LIRI 中的 PCD 正成为一个热门话题,并将继续成为该领域的热点。我们的研究可为未来有关 LIRI 的研究工作提供有价值的指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the research progression and evolutionary trends of lung ischemia-reperfusion injury: A bibliometric analysis from 1979 to 2023

Background

Lung ischemia-reperfusion injury (LIRI) poses a significant challenge in various clinical scenarios. Despite extensive research on the pathogenesis and potential treatments of LIRI, there is a notable absence of bibliometric analysis.

Materials and methods

We summarized the results of LIRI research through two searches on the Web of Science, covering data from 1979 to 2023 with topic words “lung” and “reperfusion injury”. The collected data were analyzed and visualized based on country, author(s), and keywords by bibliometric software. The keyword “programmed cell death” was further added to explore the hotspot of the LIRI research field.

Results

The initial analysis of 1648 research articles showed a total of 40 countries and 7031 researchers were involved in the publications, with America being the most productive country in the research field of LIRI. Keyword analysis revealed that the evolving focus of LIRI research has progressively transitioned from, lung transplantation, primary graft dysfunction, inflammation, oxidative stress, and ex vivo lung perfusion to cell death. Subsequently, 212 publications specifically addressing programmed cell death (PCD) in LIRI were identified, which clarified the recent hotspot of the LIRI field.

Conclusion

With closer international cooperation and increasing research scale, the LIRI research focused mainly on the pathogenesis and potential therapeutic interventions for LIRI. PCD in LIRI is becoming a trending topic and will continue to be a hotspot in this field. Our study may offer valuable guidance for future research endeavors concerning LIRI.

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来源期刊
Life sciences
Life sciences 医学-药学
CiteScore
12.20
自引率
1.60%
发文量
841
审稿时长
6 months
期刊介绍: Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.
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