D-Dimer 对非 ST 段抬高心肌梗死非糖尿病患者院内死亡率的预测价值。

IF 2.3 4区 医学 Q2 HEMATOLOGY
Bin Li, Xiaojing Liu, Miaomiao Gao, Lin Ma, Wensen Yao, Yujie Zhao
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引用次数: 0

摘要

循环 D-二聚体水平升高已被证明是多种疾病院内死亡率的预测因子,但 D-二聚体与非 ST 段抬高型心肌梗死(NSTEMI)院内预后之间的关系仍不清楚。这项回顾性研究纳入了 662 名非糖尿病 NSTEMI 患者。通过多变量分析确定了独立的风险因素,并进行了接收器操作特征(ROC)曲线分析,以比较 D-二聚体、白蛋白(ALB)和 D-二聚体与白蛋白比值(DAR)对 NSTEMI 院内死亡的预测价值。为了进一步探讨D-二聚体与死亡风险之间的线性或非线性关系,采用了带限制性立方样条(RCS)的逻辑回归模型。38例(5.7%)患者出现院内死亡。多变量分析显示,D-二聚体(每增加 500 ng)是非糖尿病 NSTEMI 患者院内死亡的独立预测因子(OR = 1.19,95% CI:1.03-1.40,P = 0.036)。D-二聚体对院内死亡率的预测性能良好,ROC曲线下面积(AUC)值为0.75(95% CI:0.66-0.83),D-二聚体、ALB(AUC = 0.70,95% CI:0.61-0.79)和DAR(AUC = 0.75,95% CI:0.66-0.84)的预测能力无显著差异。此外,RCS 分析显示 D-二聚体与院内死亡风险之间存在线性关系(非线性 P = 0.747)。D-二聚体可作为一种简单、可靠且有价值的生物标记物,用于预测非糖尿病 NSTEMI 患者的院内死亡率,并与死亡风险呈线性关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predictive Value of D-Dimer for In-Hospital Mortality in Non-Diabetic Patients with Non-ST-segment Elevation Myocardial Infarction.

Elevated circulating D-dimer levels have been shown to be a predictor of in-hospital mortality in a variety of diseases; however, the relationship between D-dimer and the in-hospital prognosis of non-ST-segment elevation myocardial infarction (NSTEMI) remains unclear. This retrospective study included 662 non-diabetic patients with NSTEMI. Independent risk factors were identified by multivariate analyses, and the receiver operating characteristic (ROC) curve analyses were performed to compare the predictive value of D-dimer, albumin (ALB), and D-dimer to albumin ratio (DAR) for in-hospital death in NSTEMI. Logistic regression model with restricted cubic spline (RCS) was used to further explore the linear or nonlinear relationship between D-dimer and the risk of death. In-hospital mortality occurred in 38 (5.7%) patients. Multivariate analysis showed that D-dimer (per increase of 500 ng) was identified as an independent predictor for in-hospital mortality in non-diabetic patients with NSTEMI (OR = 1.19, 95% CI: 1.03-1.40, P = 0.036). D-dimer demonstrated good predictive performance for in-hospital mortality with an area under the ROC curve (AUC) value of 0.75 (95% CI: 0.66-0.83), and there was no significant difference in the predictive ability of D-dimer, ALB (AUC = 0.70, 95% CI: 0.61-0.79) and DAR (AUC = 0.75, 95% CI: 0.66-0.84). In addition, RCS analysis showed a linear relationship between D-dimer and the risk of in-hospital mortality (P for nonlinear = 0.747). D-dimer can be used as a simple, reliable and valuable biomarker for predicting in-hospital mortality in non-diabetic patients with NSTEMI and is linearly associated with the risk of death.

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来源期刊
CiteScore
4.40
自引率
3.40%
发文量
150
审稿时长
2 months
期刊介绍: CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.
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