{"title":"有机引发剂引发的炔类化合物非定向 C-H 氨基化反应","authors":"Zongxing Hu, Yanhui Bai and Honghui Lei","doi":"10.1039/D4QO01196A","DOIUrl":null,"url":null,"abstract":"<p >The demand for transition-metal-free protocols in the C–H amination of aromatic compounds is significant but remains elusive. In this study, we explore the use of a picolinic acid-derived organo-initiator to facilitate undirected C–H amination of simple arenes. An investigation of substitutional effects provides valuable insights into the electronic and steric influences on C–H amination reactivity. Our protocol exhibits broad applicability in the C–H amination of various simple arenes and bioactive compounds.</p>","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":" 19","pages":" 5511-5515"},"PeriodicalIF":4.7000,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Organo-initiator enabled undirected C–H amination of arenes†\",\"authors\":\"Zongxing Hu, Yanhui Bai and Honghui Lei\",\"doi\":\"10.1039/D4QO01196A\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >The demand for transition-metal-free protocols in the C–H amination of aromatic compounds is significant but remains elusive. In this study, we explore the use of a picolinic acid-derived organo-initiator to facilitate undirected C–H amination of simple arenes. An investigation of substitutional effects provides valuable insights into the electronic and steric influences on C–H amination reactivity. Our protocol exhibits broad applicability in the C–H amination of various simple arenes and bioactive compounds.</p>\",\"PeriodicalId\":97,\"journal\":{\"name\":\"Organic Chemistry Frontiers\",\"volume\":\" 19\",\"pages\":\" 5511-5515\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Chemistry Frontiers\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2024/qo/d4qo01196a\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry Frontiers","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/qo/d4qo01196a","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Organo-initiator enabled undirected C–H amination of arenes†
The demand for transition-metal-free protocols in the C–H amination of aromatic compounds is significant but remains elusive. In this study, we explore the use of a picolinic acid-derived organo-initiator to facilitate undirected C–H amination of simple arenes. An investigation of substitutional effects provides valuable insights into the electronic and steric influences on C–H amination reactivity. Our protocol exhibits broad applicability in the C–H amination of various simple arenes and bioactive compounds.
期刊介绍:
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.