{"title":"时间同步的 2-脱氧-2-[18F]氟-D-葡萄糖 PET/MRI 与磁共振主动触发和贝叶斯惩罚似然重建：子宫内膜癌局部扩展的诊断效用","authors":"Miho Tachibana , Munenobu Nogami , Junko Inoue Inukai , Feibi Zeng , Kazuhiro Kubo , Takako Kurimoto , Martin W Huellner , Yoshiko Ueno , Takahiro Tsuboyama , Izumi Imaoka , Takamichi Murakami","doi":"10.1016/j.ejrad.2024.111678","DOIUrl":null,"url":null,"abstract":"<div><h3>PURPOSE</h3><p>Minimal misregistration of fused PET and MRI images can be achieved with simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI). However, the acquisition of multiple MRI sequences during a single PET emission scan may impair fusion precision of each sequence. This study evaluated the diagnostic utility of time-synchronized PET/MRI using an MR active trigger and a Bayesian penalized likelihood reconstruction algorithm (BPL) to assess the locoregional extension of endometrial cancer.</p></div><div><h3>METHODS</h3><p>Fifty-five patients with endometrial cancer who underwent pelvic 2-deoxy-2-[<sup>18</sup>F]fluoro-D-glucose PET/MRI were retrospectively evaluated. The PET emission time for the BPL reconstruction was determined by the MR active trigger of each MR sequence. The concordance rates of image interpretation with pathological T-staging, diagnostic performance for deep myometrial invasion (MI), and diagnostic confidence levels were evaluated by two readers and compared between time-synchronized, overlapping (conventional and simultaneous, but not time-synchronized), and sequential (not simultaneous) PET/MRI and MRI with diffusion-weighted imaging. Misregistration of the PET/MRI-fused images was determined by evaluating the differences in bladder dimensions.</p></div><div><h3>RESULTS</h3><p>The T classification by time-synchronized PET/MRI was the most concordant with the pathological T classification for the two readers. Time-synchronized PET/MRI had a significantly higher diagnostic performance for deep MI and higher confidence level scores than overlapping PET/MRI for the novice reader (<em>p</em> = 0.033 and <em>p</em> = 0.038, respectively). The differences in bladder dimension on sequential PET/MRI were significantly larger than those on overlapping and time-synchronized PET/MRI (<em>p</em> <0.001).</p></div><div><h3>CONCLUSION</h3><p>Time-synchronized PET/MRI is superior to conventional PET/MRI for assessing the locoregional extension of endometrial cancer.</p></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"179 ","pages":"Article 111678"},"PeriodicalIF":3.2000,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0720048X24003942/pdfft?md5=776d58d9a486ed225646a1cf5d34fdc2&pid=1-s2.0-S0720048X24003942-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Time-synchronized 2-deoxy-2-[18F]fluoro-D-glucose PET/MRI with MR-active trigger and Bayesian penalized likelihood reconstruction: Diagnostic utility for locoregional extension of endometrial cancer\",\"authors\":\"Miho Tachibana , Munenobu Nogami , Junko Inoue Inukai , Feibi Zeng , Kazuhiro Kubo , Takako Kurimoto , Martin W Huellner , Yoshiko Ueno , Takahiro Tsuboyama , Izumi Imaoka , Takamichi Murakami\",\"doi\":\"10.1016/j.ejrad.2024.111678\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>PURPOSE</h3><p>Minimal misregistration of fused PET and MRI images can be achieved with simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI). However, the acquisition of multiple MRI sequences during a single PET emission scan may impair fusion precision of each sequence. This study evaluated the diagnostic utility of time-synchronized PET/MRI using an MR active trigger and a Bayesian penalized likelihood reconstruction algorithm (BPL) to assess the locoregional extension of endometrial cancer.</p></div><div><h3>METHODS</h3><p>Fifty-five patients with endometrial cancer who underwent pelvic 2-deoxy-2-[<sup>18</sup>F]fluoro-D-glucose PET/MRI were retrospectively evaluated. The PET emission time for the BPL reconstruction was determined by the MR active trigger of each MR sequence. The concordance rates of image interpretation with pathological T-staging, diagnostic performance for deep myometrial invasion (MI), and diagnostic confidence levels were evaluated by two readers and compared between time-synchronized, overlapping (conventional and simultaneous, but not time-synchronized), and sequential (not simultaneous) PET/MRI and MRI with diffusion-weighted imaging. Misregistration of the PET/MRI-fused images was determined by evaluating the differences in bladder dimensions.</p></div><div><h3>RESULTS</h3><p>The T classification by time-synchronized PET/MRI was the most concordant with the pathological T classification for the two readers. Time-synchronized PET/MRI had a significantly higher diagnostic performance for deep MI and higher confidence level scores than overlapping PET/MRI for the novice reader (<em>p</em> = 0.033 and <em>p</em> = 0.038, respectively). The differences in bladder dimension on sequential PET/MRI were significantly larger than those on overlapping and time-synchronized PET/MRI (<em>p</em> <0.001).</p></div><div><h3>CONCLUSION</h3><p>Time-synchronized PET/MRI is superior to conventional PET/MRI for assessing the locoregional extension of endometrial cancer.</p></div>\",\"PeriodicalId\":12063,\"journal\":{\"name\":\"European Journal of Radiology\",\"volume\":\"179 \",\"pages\":\"Article 111678\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-08-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0720048X24003942/pdfft?md5=776d58d9a486ed225646a1cf5d34fdc2&pid=1-s2.0-S0720048X24003942-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0720048X24003942\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Radiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0720048X24003942","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
目的通过同步正电子发射断层扫描/磁共振成像（PET/MRI），可将 PET 和 MRI 图像的融合误差降至最低。然而，在一次正电子发射扫描过程中采集多个磁共振成像序列可能会影响每个序列的融合精度。本研究评估了使用磁共振主动触发器和贝叶斯惩罚似然重建算法（BPL）的时间同步 PET/MRI 在评估子宫内膜癌局部扩展方面的诊断效用。BPL 重建的 PET 发射时间由每个 MR 序列的 MR 激活触发器决定。由两名阅读者评估图像解读与病理T分期的吻合率、子宫深部浸润（MI）的诊断性能和诊断置信度，并比较时间同步、重叠（常规和同步，但非时间同步）和顺序（非同步）PET/MRI与弥散加权成像核磁共振之间的差异。结果时间同步 PET/MRI 的 T 分类与两位读者的病理 T 分类最为一致。与重叠 PET/MRI 相比，时间同步 PET/MRI 对深度 MI 的诊断率明显更高，对新手读者的置信度评分也更高（分别为 p = 0.033 和 p = 0.038）。结论在评估子宫内膜癌的局部扩展方面，时间同步 PET/MRI 优于传统 PET/MRI。
Time-synchronized 2-deoxy-2-[18F]fluoro-D-glucose PET/MRI with MR-active trigger and Bayesian penalized likelihood reconstruction: Diagnostic utility for locoregional extension of endometrial cancer
PURPOSE
Minimal misregistration of fused PET and MRI images can be achieved with simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI). However, the acquisition of multiple MRI sequences during a single PET emission scan may impair fusion precision of each sequence. This study evaluated the diagnostic utility of time-synchronized PET/MRI using an MR active trigger and a Bayesian penalized likelihood reconstruction algorithm (BPL) to assess the locoregional extension of endometrial cancer.
METHODS
Fifty-five patients with endometrial cancer who underwent pelvic 2-deoxy-2-[18F]fluoro-D-glucose PET/MRI were retrospectively evaluated. The PET emission time for the BPL reconstruction was determined by the MR active trigger of each MR sequence. The concordance rates of image interpretation with pathological T-staging, diagnostic performance for deep myometrial invasion (MI), and diagnostic confidence levels were evaluated by two readers and compared between time-synchronized, overlapping (conventional and simultaneous, but not time-synchronized), and sequential (not simultaneous) PET/MRI and MRI with diffusion-weighted imaging. Misregistration of the PET/MRI-fused images was determined by evaluating the differences in bladder dimensions.
RESULTS
The T classification by time-synchronized PET/MRI was the most concordant with the pathological T classification for the two readers. Time-synchronized PET/MRI had a significantly higher diagnostic performance for deep MI and higher confidence level scores than overlapping PET/MRI for the novice reader (p = 0.033 and p = 0.038, respectively). The differences in bladder dimension on sequential PET/MRI were significantly larger than those on overlapping and time-synchronized PET/MRI (p <0.001).
CONCLUSION
Time-synchronized PET/MRI is superior to conventional PET/MRI for assessing the locoregional extension of endometrial cancer.
期刊介绍：
European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field.
Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.
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