Martha Petrovick, Anna Shcherbina, Emily K Farina, Lauren A Thompson, Philip J Niro, James P McClung, Harris R Lieberman
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Ability to adapt to stress is resilience.</p><p><strong>Objectives: </strong>This study investigated genetic factors associated with resilience in soldiers exposed to severe stress due to intense physical and mental demands at Survive, Evade, Resist and Escape school, a unique environment to study acute stress and resiliency in real-world circumstances.</p><p><strong>Design: </strong>A preliminary correlational study was conducted to identify genetic markers for resilience to stress.</p><p><strong>Methods: </strong>Mood state, resiliency and dissociative state of 73 soldiers were assessed using: Connor-Davidson Resilience Scale (CD-RISC); Profile of Mood States (POMS); and Clinician-Administered Dissociative States Scale (CADSS). Change scores for resilience-related stress markers were computed; 116 single nucleotide polymorphisms (SNPs) associated with stress, depression, anxiety, sleep, or psychiatric disorders were assessed.</p><p><strong>Results: </strong>A significant association between change in CD-RISC score and SNP rs4251417, present in an intron of SLC6A4, the serotonin transporter gene, was observed.</p><p><strong>Conclusions: </strong>Individuals with the minor allele of SNP rs4251417 had a greater positive change in CD-RISC, indicating increased self-assessed resilience. This study suggests the minor allele of SNP rs4251417 of SLC6A4 is associated with resilience when individuals are exposed to high stress.</p>","PeriodicalId":51415,"journal":{"name":"Anxiety Stress and Coping","volume":" ","pages":"1-20"},"PeriodicalIF":2.3000,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The minor allele of the serotonin transporter gene variant rs4251417 is associated with increased resilience in soldiers experiencing acute stress during survival training: preliminary findings.\",\"authors\":\"Martha Petrovick, Anna Shcherbina, Emily K Farina, Lauren A Thompson, Philip J Niro, James P McClung, Harris R Lieberman\",\"doi\":\"10.1080/10615806.2024.2388850\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Variation in cognitive, emotional and physical performance in response to stress is attributable to environmental and genetic factors. 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引用次数: 0
摘要
背景:环境和遗传因素会导致人们在应对压力时在认知、情绪和身体表现方面出现差异。适应压力的能力就是复原力:本研究调查了在 "生存、躲避、抵抗和逃生 "学校中因强烈的身体和精神需求而面临严重压力的士兵中与恢复力相关的遗传因素:设计:开展一项初步相关研究,以确定抗压能力的遗传标记:方法:使用以下方法对 73 名士兵的情绪状态、复原力和分离状态进行评估:康纳-戴维森复原力量表(CD-RISC)、情绪状态档案(POMS)和临床医师管理的分离状态量表(CADSS)。计算了复原力相关压力标记的变化分数;评估了与压力、抑郁、焦虑、睡眠或精神障碍相关的116个单核苷酸多态性(SNPs):结果:CD-RISC 评分的变化与 SNP rs4251417(位于血清素转运体基因 SLC6A4 的一个内含子上)之间存在明显关联:结论:具有 SNP rs4251417 小等位基因的个体在 CD-RISC 中的正向变化更大,表明自我评估的复原力有所增强。这项研究表明,SLC6A4 SNP rs4251417的小等位基因与个体在高压力下的恢复力有关。
The minor allele of the serotonin transporter gene variant rs4251417 is associated with increased resilience in soldiers experiencing acute stress during survival training: preliminary findings.
Background: Variation in cognitive, emotional and physical performance in response to stress is attributable to environmental and genetic factors. Ability to adapt to stress is resilience.
Objectives: This study investigated genetic factors associated with resilience in soldiers exposed to severe stress due to intense physical and mental demands at Survive, Evade, Resist and Escape school, a unique environment to study acute stress and resiliency in real-world circumstances.
Design: A preliminary correlational study was conducted to identify genetic markers for resilience to stress.
Methods: Mood state, resiliency and dissociative state of 73 soldiers were assessed using: Connor-Davidson Resilience Scale (CD-RISC); Profile of Mood States (POMS); and Clinician-Administered Dissociative States Scale (CADSS). Change scores for resilience-related stress markers were computed; 116 single nucleotide polymorphisms (SNPs) associated with stress, depression, anxiety, sleep, or psychiatric disorders were assessed.
Results: A significant association between change in CD-RISC score and SNP rs4251417, present in an intron of SLC6A4, the serotonin transporter gene, was observed.
Conclusions: Individuals with the minor allele of SNP rs4251417 had a greater positive change in CD-RISC, indicating increased self-assessed resilience. This study suggests the minor allele of SNP rs4251417 of SLC6A4 is associated with resilience when individuals are exposed to high stress.
期刊介绍:
This journal provides a forum for scientific, theoretically important, and clinically significant research reports and conceptual contributions. It deals with experimental and field studies on anxiety dimensions and stress and coping processes, but also with related topics such as the antecedents and consequences of stress and emotion. We also encourage submissions contributing to the understanding of the relationship between psychological and physiological processes, specific for stress and anxiety. Manuscripts should report novel findings that are of interest to an international readership. While the journal is open to a diversity of articles.