对 Chen 等人（2022 年）的评论：需要继续开展方法学研究，利用次要终点信息提高 RCT 的效率。

IF 2 3区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Contemporary clinical trials Pub Date : 2024-08-18 DOI:10.1016/j.cct.2024.107664

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引用次数: 0

摘要

Chen 等人（2022 年）最近提出了一套估算方程，将次要终点的数据纳入其中，以提高与主要终点相关的参数估计的精确度。我们的动机是将他们的方法转化到随机对照试验中，利用次要终点数据提高治疗效果估计的精确度。我们的研究结果表明，在这种情况下，由于随机治疗分配的原因，这种估计方法无法提高效率，尤其是在次要终点存在治疗效果的情况下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Commentary on Chen et al. (2022): The need for continued methodological research on leveraging information in secondary endpoints for more efficient RCTs

Chen et al. (2022) recently proposed a set of estimating equations that incorporate data from secondary endpoints to improve precision in parameter estimates related to a primary endpoint. We were motivated to translate their methodology to the context of randomized controlled trials to gain precision in treatment effect estimation using data from secondary endpoints. Our results suggest that this estimator cannot gain efficiency in this context because of random treatment assignment, especially when there is a treatment effect on secondary endpoints, and that further methodological work in this area is needed.

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来源期刊

Contemporary clinical trials 医学-药学

CiteScore

3.70

自引率

4.50%

发文量

281

审稿时长

44 days

期刊介绍： Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.