作为儿科疾病诊断和预后生物标志物的 Copeptin。

IF 3.8 2区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Xiaoli Shu, Fengqing Cai, Wei Li, Hongqiang Shen
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引用次数: 0

摘要

精氨酸加压素(AVP)在维持体液平衡和血管张力的稳态以及调节内分泌对渗透压、血流动力学和压力刺激的应激反应方面发挥着主要作用。然而,测量 AVP 的困难限制了其临床应用。蛋白肽是 AVP 前体的 C 端部分,它与 AVP 以等摩尔浓度模式从垂体释放,但更稳定、更易于测量。因此,近几十年来, copeptin 已成为 AVP 的替代标记物,在各种疾病的诊断、鉴别和预后方面具有良好的潜力。然而,其应用还需要进一步验证,尤其是在儿科人群中。本综述将重点探讨 copeptin 在不同儿科疾病中的临床价值及其作为潜在生物标记物的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Copeptin as a diagnostic and prognostic biomarker in pediatric diseases.

Arginine vasopressin (AVP) plays a main role in maintaining the homeostasis of fluid balance and vascular tone and in regulating the endocrine stress response in response to osmotic, hemodynamic and stress stimuli. However, the difficulty in measuring AVP limits its clinical application. Copeptin, the C-terminal part of the AVP precursor, is released in an equimolar concentration mode with AVP from the pituitary but is more stable and simple to measure. Therefore, copeptin has emerged as a promising surrogate marker of AVP with excellent potential for the diagnosis, differentiation and prognosis of various diseases in recent decades. However, its application requires further validation, especially in the pediatric population. This review focuses on the clinical value of copeptin in different pediatric diseases and the prospects for its application as a potential biomarker.

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来源期刊
Clinical chemistry and laboratory medicine
Clinical chemistry and laboratory medicine 医学-医学实验技术
CiteScore
11.30
自引率
16.20%
发文量
306
审稿时长
3 months
期刊介绍: Clinical Chemistry and Laboratory Medicine (CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor over 3. CCLM is issued monthly, and it is published in print and electronically. CCLM is the official journal of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) and publishes regularly EFLM recommendations and news. CCLM is the official journal of the National Societies from Austria (ÖGLMKC); Belgium (RBSLM); Germany (DGKL); Hungary (MLDT); Ireland (ACBI); Italy (SIBioC); Portugal (SPML); and Slovenia (SZKK); and it is affiliated to AACB (Australia) and SFBC (France). Topics: - clinical biochemistry - clinical genomics and molecular biology - clinical haematology and coagulation - clinical immunology and autoimmunity - clinical microbiology - drug monitoring and analysis - evaluation of diagnostic biomarkers - disease-oriented topics (cardiovascular disease, cancer diagnostics, diabetes) - new reagents, instrumentation and technologies - new methodologies - reference materials and methods - reference values and decision limits - quality and safety in laboratory medicine - translational laboratory medicine - clinical metrology Follow @cclm_degruyter on Twitter!
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