{"title":"在使用全血的时代，与使用血液制品相关的静脉血栓栓塞事件。","authors":"","doi":"10.1016/j.amjsurg.2024.115887","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The risks associated with blood product administration and venous thromboembolic events remains unclear. We sought to determine which blood products were associated with the development of deep vein thrombosis (DVT) and pulmonary embolism (PE).</p></div><div><h3>Methods</h3><p>We analyzed data from patients ≥18 years of age in the Trauma Quality Improvement Program (TQIP) database that received ≥1 blood product and survived ≥24 h.</p></div><div><h3>Results</h3><p>There were 42,399 that met inclusion, of whom, 2086 had at least one VTE event. In our multivariable logistic regression model, we found that WB had a unit odds ratio (uOR) of 1.05 (95 % CI 1.02–1.08) for DVT and 1.08 (1.05–1.12) for PE. Compared to WB, platelets had a higher uOR for DVT of 1.09 (1.04–1.13) but similar uOR for PE of 1.08 (1.03–1.14).</p></div><div><h3>Conclusions</h3><p>We found an association of both DVT and PE with early whole blood and platelets.</p></div>","PeriodicalId":7771,"journal":{"name":"American journal of surgery","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Venous thromboembolic events associated with blood product administration in an era of whole blood use\",\"authors\":\"\",\"doi\":\"10.1016/j.amjsurg.2024.115887\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The risks associated with blood product administration and venous thromboembolic events remains unclear. We sought to determine which blood products were associated with the development of deep vein thrombosis (DVT) and pulmonary embolism (PE).</p></div><div><h3>Methods</h3><p>We analyzed data from patients ≥18 years of age in the Trauma Quality Improvement Program (TQIP) database that received ≥1 blood product and survived ≥24 h.</p></div><div><h3>Results</h3><p>There were 42,399 that met inclusion, of whom, 2086 had at least one VTE event. In our multivariable logistic regression model, we found that WB had a unit odds ratio (uOR) of 1.05 (95 % CI 1.02–1.08) for DVT and 1.08 (1.05–1.12) for PE. Compared to WB, platelets had a higher uOR for DVT of 1.09 (1.04–1.13) but similar uOR for PE of 1.08 (1.03–1.14).</p></div><div><h3>Conclusions</h3><p>We found an association of both DVT and PE with early whole blood and platelets.</p></div>\",\"PeriodicalId\":7771,\"journal\":{\"name\":\"American journal of surgery\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-08-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0002961024004392\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of surgery","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0002961024004392","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
摘要
背景：血液制品用药与静脉血栓栓塞事件相关的风险仍不清楚。我们试图确定哪些血液制品与深静脉血栓（DVT）和肺栓塞（PE）的发生有关：我们分析了创伤质量改进计划（TQIP）数据库中年龄≥18岁、接受过≥1次血液制品且存活≥24小时的患者的数据：符合纳入条件的有 42,399 人，其中 2086 人至少发生过一次 VTE 事件。在我们的多变量逻辑回归模型中，我们发现白细胞与深静脉血栓形成的单位几率比（uOR）为 1.05（95 % CI 1.02-1.08），与 PE 的单位几率比（uOR）为 1.08（1.05-1.12）。与白细胞相比，血小板对深静脉血栓的单位几率更高，为 1.09（1.04-1.13），但对 PE 的单位几率相似，为 1.08（1.03-1.14）：我们发现深静脉血栓形成和血小板减少与早期全血和血小板有关。
Venous thromboembolic events associated with blood product administration in an era of whole blood use
Background
The risks associated with blood product administration and venous thromboembolic events remains unclear. We sought to determine which blood products were associated with the development of deep vein thrombosis (DVT) and pulmonary embolism (PE).
Methods
We analyzed data from patients ≥18 years of age in the Trauma Quality Improvement Program (TQIP) database that received ≥1 blood product and survived ≥24 h.
Results
There were 42,399 that met inclusion, of whom, 2086 had at least one VTE event. In our multivariable logistic regression model, we found that WB had a unit odds ratio (uOR) of 1.05 (95 % CI 1.02–1.08) for DVT and 1.08 (1.05–1.12) for PE. Compared to WB, platelets had a higher uOR for DVT of 1.09 (1.04–1.13) but similar uOR for PE of 1.08 (1.03–1.14).
Conclusions
We found an association of both DVT and PE with early whole blood and platelets.
期刊介绍：
The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.
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