调节帕金森病神经炎症的微RNAs

IF 4.5 2区 医学 Q2 CELL BIOLOGY
Mohamed J Saadh, Faris Anad Muhammad, Anamika Singh, Mohammed Ahmed Mustafa, Rafil Adnan Hussein Al Zuhairi, Pallavi Ghildiyal, Ghassan Hashim, Fahad Alsaikhan, Shayan Khalilollah, Reza Akhavan-Sigari
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引用次数: 0

摘要

帕金森病(PD)是最常见的与年龄相关的神经退行性疾病之一。帕金森病的特征之一是黑质(SNpc)中含有α-突触核蛋白的聚集体和多巴胺能(DA)神经元的缺失。慢性神经炎症是帕金森病病理生理学的标志之一。神经胶质细胞的活化和促炎因子水平的升高已被证实是帕金森病大脑的常见特征。活化的星形胶质细胞和小胶质细胞长期分泌促炎细胞因子,加剧了SNpc中DA神经元的退化。微小RNA(miRNA)是一种内源性非编码小RNA,具有对靶基因进行转录后调控的能力。在这方面,miRNAs 调节炎症信号转导的能力是许多研究关注的焦点。MiRNAs 可增强或限制炎症信号转导,加剧或改善极端神经炎症的病理后果。本综述总结了炎症在帕金森病病理生理学中的重要性。此外,我们还讨论了 miRNA 在通过控制炎症通路促进或保护帕金森病模型中神经细胞损伤方面的作用。通过 miRNAs 改变神经炎症可被视为一种治疗帕金森病的主要策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

MicroRNAs Modulating Neuroinflammation in Parkinson's disease.

MicroRNAs Modulating Neuroinflammation in Parkinson's disease.

Parkinson's disease (PD) is one of the most frequent age-associated neurodegenerative disorder. Presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc) and loss of dopaminergic (DA) neurons are among the characteristic of PD. One of the hallmarks of PD pathophysiology is chronic neuroinflammation. Activation of glial cells and elevated levels of pro-inflammatory factors are confirmed as frequent features of the PD brain. Chronic secretion of pro-inflammatory cytokines by activated astrocytes and microglia exacerbates DA neuron degeneration in the SNpc. MicroRNAs (miRNAs) are among endogenous non-coding small RNA with the ability to perform post-transcriptional regulation in target genes. In that regard, the capability of miRNAs for modulating inflammatory signaling is the center of attention in many investigations. MiRNAs could enhance or limit inflammatory signaling, exacerbating or ameliorating the pathological consequences of extreme neuroinflammation. This review summarizes the importance of inflammation in the pathophysiology of PD. Besides, we discuss the role of miRNAs in promoting or protecting neural cell injury in the PD model by controlling the inflammatory pathway. Modifying the neuroinflammation by miRNAs could be considered a primary therapeutic strategy for PD.

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来源期刊
Inflammation
Inflammation 医学-免疫学
CiteScore
9.70
自引率
0.00%
发文量
168
审稿时长
3.0 months
期刊介绍: Inflammation publishes the latest international advances in experimental and clinical research on the physiology, biochemistry, cell biology, and pharmacology of inflammation. Contributions include full-length scientific reports, short definitive articles, and papers from meetings and symposia proceedings. The journal''s coverage includes acute and chronic inflammation; mediators of inflammation; mechanisms of tissue injury and cytotoxicity; pharmacology of inflammation; and clinical studies of inflammation and its modification.
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