Ji-Hee Sung, Kyung-Soo Kim, Kyungdo Han, Cheol-Young Park
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引用次数: 0
摘要
背景:我们研究了年轻女性中子宫纵膈肌瘤(UL)与2型糖尿病(T2DM)发病之间的关系:我们研究了年轻女性中子宫肌瘤(UL)与2型糖尿病(T2DM)发病之间的关系:方法:我们利用全国健康信息数据库对 2,541,550 名年龄在 20 至 40 岁之间的女性进行了一项全国性人群队列研究。结果:平均年龄为 29.70 岁:平均年龄为 29.70 岁,平均体重指数为 21.31 kg/m2。在 2,541,550 名参与者中,18,375 名女性(0.72%)患有 UL。在中位 7.45 年的随访期间,23829 名妇女(0.94%)被诊断出患有 T2DM。患有 UL 的女性 T2DM 发病率(1.805/1,000 人-年)高于未患有 UL 的女性(1.289/1,000 人-年)。与没有 UL 的女性相比,患有 UL 的女性发生 T2DM 的风险更高(危险比为 1.216;95% 置信区间 [CI],1.071 至 1.382)。未接受子宫肌瘤切除术的 UL 女性发生 T2DM 的风险是未接受 UL 女性的 1.505 倍(95% 置信区间 [CI],1.297 至 1.748)。然而,接受子宫肌瘤切除术的 UL 女性发生 T2DM 的风险并没有增加:结论:患有 UL 的年轻女性发生 T2DM 的风险很高。结论:患有超低密度脂蛋白血症的年轻女性发生 T2DM 的风险很高,而子宫肌瘤切除术似乎可以降低患有超低密度脂蛋白血症的年轻女性发生 T2DM 的风险。
Association of Uterine Leiomyoma with Type 2 Diabetes Mellitus in Young Women: A Population-Based Cohort Study.
Backgruound: We investigated the association between uterine leiomyoma (UL) and incident type 2 diabetes mellitus (T2DM) in young women.
Methods: A nationwide population-based cohort study of 2,541,550 women aged between 20 and 40 years was performed using the National Health Information Database. Cox proportional hazards models were used to analyze the risk of incident T2DM according to the presence of UL and myomectomy.
Results: The mean age was 29.70 years, and mean body mass index was 21.31 kg/m2. Among 2,541,550 participants, 18,375 (0.72%) women had UL. During a median 7.45 years of follow-up, 23,829 women (0.94%) were diagnosed with T2DM. The incidence of T2DM in women with UL (1.805/1,000 person-years) was higher than in those without UL (1.289/1,000 person-years). Compared with women without UL, women with UL had a higher risk of incident T2DM (hazard ratio, 1.216; 95% confidence interval [CI], 1.071 to 1.382). Women with UL who did not undergo myomectomy had a 1.505 times (95% CI, 1.297 to 1.748) higher risk for incident T2DM than women without UL. However, women with UL who underwent myomectomy did not have increased risk for incident T2DM.
Conclusion: Young women with UL were associated with a high risk of incident T2DM. In addition, myomectomy seemed to attenuate the risk for incident T2DM in young women with UL.
期刊介绍:
The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies.
The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication.
The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.