以 PI3K/AKT 和 MEK/ERK 通路为靶点，协同改善糖尿病周围神经病变的特征。

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2024-08-20 DOI:10.1111/jdi.14289

Vuong M. Pham

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引用次数: 0

摘要

糖尿病神经病变是糖尿病最严重、最常见的并发症之一，病变范围很广，30%-50% 的糖尿病患者都会受到影响。然而，目前治疗这种疾病的主要方法是控制血糖水平，但临床效果并不理想。我们需要更好的方法。因此，促进神经再生和预防神经变性应得到同等和适当的重视。在这篇微型综述中，我们将讨论在治疗糖尿病周围神经病变时，如何更有效地靶向 PI3K/AKT 和 MEK/ERK 通路。未来的糖尿病周围神经病变治疗应考虑这些方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Targeting PI3K/AKT and MEK/ERK pathways for synergic effects on improving features of peripheral diabetic neuropathy

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Targeting PI3K/AKT and MEK/ERK pathways for synergic effects on improving features of peripheral diabetic neuropathy

Diabetic neuropathy is one of the most serious and common complications of diabetes with a wide spectrum, affecting 30–50% of diabetic patients. However, the current treatments of this disorder, mainly based on controlling blood glucose level, show an inadequate clinical outcome. Better approaches are needed. In this fashion, it is noted that promoting nerve regeneration and preventing nerve degeneration should be focused on equally and appropriately. In this mini review, how more effective approaches are in targeting PI3K/AKT and MEK/ERK pathways in the treatment of peripheral diabetic neuropathy is discussed. Future treatment of peripheral diabetic neuropathy should consider these approaches.

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).