透析相关肌肉痉挛的药物治疗:系统回顾。

IF 1.4 4区 医学 Q3 UROLOGY & NEPHROLOGY
Seminars in Dialysis Pub Date : 2024-11-01 Epub Date: 2024-08-18 DOI:10.1111/sdi.13223
Nidia Mantilla-Manosalva, Santiago Guadarrama, Lennis Jazmin Bedoya-Muñoz, Sara Giraldo-Moreno, Laura Cuellar-Valencia, María Fernanda Iriarte-Aristizábal, Marta Ximena León, Fernan Alejandro Mendoza-Montenegro, Juan Esteban Correa-Morales
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引用次数: 0

摘要

背景:目的:治疗透析相关肌肉痉挛的药物干预的有效性和安全性如何?截至 2023 年 8 月 25 日,在 OVID、CINAHL、PubMed、Web of Science 和 Cochrane 中心数据库中进行了系统综述:数据来源:纳入了有关药物干预治疗透析相关肌肉痉挛的实验研究。综述遵循《系统综述和荟萃分析首选报告项目》,并使用 RoB2 工具对研究质量进行评估:结果:共检索到 4660 项研究,纳入 13 篇文章。这些研究报告了九种干预措施:维生素 C、维生素 E、维生素 K2、维生素 B7、葡萄糖溶液、加巴喷丁、氯化钠、一水肌酸和左旋肉碱。测试左旋肉碱和一水肌酸的研究是唯一被认为偏倚风险较低的研究。只有两项试验报告了副作用,主要是胃肠道不适和高血糖。维生素 C 和维生素 E 是研究最多的两种干预措施,它们在减少透析相关肌肉痉挛的频率、严重程度和持续时间方面都取得了积极的效果。左旋肉碱是一种很有前景的干预措施,值得进一步研究:我们的综述整合了现有的证据,阐明了各种治疗方法及其潜在的益处和局限性。未来的研究应坚持高质量标准,纳入患者报告的结果,并利用定义明确、可靠的样本来改善患者护理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmacological Treatment for Dialysis-Related Muscle Cramps: A Systematic Review.

Background: Patients with end-stage renal disease undergoing dialysis suffer from muscle cramps, a prevalent and burdensome symptom for which there is a paucity of efficient and safe treatments.

Aim: What is the efficacy and safety of pharmacological interventions for the treatment of dialysis-related muscle cramps?

Design: A systematic review was conducted in OVID, CINAHL, PubMed, Web of Science, and Central Cochrane databases up to August 25, 2023.

Data sources: Experimental studies reporting on a pharmacological intervention for the treatment of dialysis-related muscle cramps were included. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis, and the studies quality was assessed with the RoB2 tool.

Results: A total of 4660 studies were retrieved, and 13 articles were included. The studies reported on nine interventions: vitamin C, vitamin E, vitamin K2, vitamin B7, dextrose solutions, gabapentin, sodium chloride, creatine monohydrate, and L-carnitine. The studies testing L-carnitine and creatine monohydrate were the only ones deemed to have a low risk of bias. Side effects were reported in only two trials, consisting primarily of gastrointestinal discomfort and hyperglycemia. Vitamins C and E are the two most studied interventions that showed positive results in reducing the frequency, severity, and duration of dialysis-related muscle cramps. L-carnitine is a promising intervention that warrants further investigation.

Conclusion: Our review consolidates the existing evidence, elucidating the range of treatments along with their potential benefits and limitations. Future studies should uphold high-quality standards, incorporate patient-reported outcomes, and utilize well-defined, robust samples to improve patient care.

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来源期刊
Seminars in Dialysis
Seminars in Dialysis 医学-泌尿学与肾脏学
CiteScore
3.00
自引率
6.20%
发文量
91
审稿时长
4-8 weeks
期刊介绍: Seminars in Dialysis is a bimonthly publication focusing exclusively on cutting-edge clinical aspects of dialysis therapy. Besides publishing papers by the most respected names in the field of dialysis, the Journal has unique useful features, all designed to keep you current: -Fellows Forum -Dialysis rounds -Editorials -Opinions -Briefly noted -Summary and Comment -Guest Edited Issues -Special Articles Virtually everything you read in Seminars in Dialysis is written or solicited by the editors after choosing the most effective of nine different editorial styles and formats. They know that facts, speculations, ''how-to-do-it'' information, opinions, and news reports all play important roles in your education and the patient care you provide. Alternate issues of the journal are guest edited and focus on a single clinical topic in dialysis.
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