儿童白血病肿瘤溶解综合征的风险因素和预测评分模型的开发:泰国一家三级医院 10 年来的经验。

IF 2.2 4区 医学 Q3 HEMATOLOGY
Leukemia & Lymphoma Pub Date : 2024-12-01 Epub Date: 2024-08-18 DOI:10.1080/10428194.2024.2390582
Pharsai Prasertsan, Edward B McNeil, Natsaruth Songthawee, Shevachut Chavananon, Pornpun Sripornsawan, Thampapon Chaisujyakorn, Thirachit Chotsampancharoen
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引用次数: 0

摘要

2009-2019年期间,泰国一家三级医疗中心对252名儿童白血病患者的肿瘤溶解综合征(TLS)进行了回顾性评估。51例(20.2%)患者在诱导化疗期间出现了TLS;60.7%(31/51)为自发性TLS,47%(24/51)为临床TLS。预测评分模型包括白细胞(WBC)计数大于 50,000 cells/mm3 、肾小球滤过率小于 90 和天门冬氨酸转氨酶大于 44 单位/L。低危、中危和高危组的 TLS 发生率分别为 11.1%、46.2% 和 78.5%。有TLS的患者在第一诱导阶段的死亡人数明显高于无TLS的患者。不过,有TLS和没有TLS的患儿的5年总生存率没有明显差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk factors and development of a predictive score model for tumor lysis syndrome in childhood leukemia: a 10-year experience from a single tertiary hospital in Thailand.

Tumor lysis syndrome (TLS) in childhood leukemia was assessed retrospectively in 252 patients in a single tertiary center in Thailand during 2009-2019. Fifty-one (20.2%) developed TLS during their induction chemotherapy; 60.7% (31/51) were spontaneous TLS and 47% (24/51) developed clinical TLS. The predictive score model consisted of white blood cell (WBC) count more than 50,000 cells/mm3, glomerular filtration rate less than 90, and aspartate transaminase more than 44 units/L. The TLS development rates were 11.1%, 46.2%, and 78.5% in the low, intermediate, and high-risk groups, respectively. Death during the first induction phase in patients with TLS was significantly higher than in the patients without TLS. However, the 5-year overall survival rates for the children with and without TLS were not significantly different.

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来源期刊
Leukemia & Lymphoma
Leukemia & Lymphoma 医学-血液学
CiteScore
4.10
自引率
3.80%
发文量
384
审稿时长
1.8 months
期刊介绍: Leukemia & Lymphoma in its fourth decade continues to provide an international forum for publication of high quality clinical, translational, and basic science research, and original observations relating to all aspects of hematological malignancies. The scope ranges from clinical and clinico-pathological investigations to fundamental research in disease biology, mechanisms of action of novel agents, development of combination chemotherapy, pharmacology and pharmacogenomics as well as ethics and epidemiology. Submissions of unique clinical observations or confirmatory studies are considered and published as Letters to the Editor
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