揭示阿托品在各种疾病中的多方面作用(综述)。

IF 5.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
International journal of molecular medicine Pub Date : 2024-10-01 Epub Date: 2024-08-19 DOI:10.3892/ijmm.2024.5414
Ling Chen, Jianrao Lu, Jing Hu, Xuezhong Gong
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引用次数: 0

摘要

Adropin 是一种由能量平衡相关基因编码的分泌肽,也是一种促进细胞间交流的膜结合蛋白。已在多种组织和体液中检测到这种肽,包括脑、肝、肾、心脏、胰腺、小肠、内皮细胞和初乳。值得注意的是,人、小鼠和大鼠体内的阿陀罗肽氨基酸序列完全相同。以往的研究表明,在不同的生理和病理条件下,阿动蛋白的水平会发生波动。阿托品在调节碳水化合物代谢、脂质代谢和细胞间分子信号通路方面发挥作用,与许多疾病的进展有关,如急性心肌梗塞、肺损伤、非酒精性脂肪肝/非酒精性脂肪性肝炎、肾脏疾病、多囊卵巢综合征、肥胖症、糖尿病、动脉粥样硬化、系统性硬化和癌症。尽管该蛋白具有重要意义,但人们对其确切作用和机制的了解和研究仍然不足。为了阐明阿糖腺苷的功能及其临床研究现状,我们对近期有关各种疾病的阿糖腺苷研究进行了系统回顾。此外,还指出了在动物和临床背景下与阿拖品研究相关的一些挑战和局限性,旨在为未来的研究提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unveiling the multifaceted role of adropin in various diseases (Review).

Adropin is a secreted peptide encoded by the energy homeostasis‑associated gene, which also functions as a membrane‑bound protein facilitating intercellular communication. This peptide has been detected in various tissues and body fluids, including the brain, liver, kidney, heart, pancreas, small intestine, endothelial cells and colostrum. Notably, the amino acid sequences of adropin are identical in humans, mice and rats. Previous studies have demonstrated that adropin levels fluctuate under different physiological and pathological conditions. Adropin plays a role in regulating carbohydrate metabolism, lipid metabolism and intercellular molecular signaling pathways, implicating its involvement in the progression of numerous diseases, such as acute myocardial infarction, lung injury, non‑alcoholic fatty liver disease/non‑alcoholic steatohepatitis, kidney disease, polycystic ovary syndrome, obesity, and diabetes, atherosclerosis, systemic sclerosis and cancer. Despite its significance, the precise role and mechanism of this protein remain inadequately understood and studied. To elucidate the function of adropin and its clinical research status, a systematic review of recent studies on adropin across various diseases was conducted. Additionally, several challenges and limitations associated with adropin research in both animal and clinical contexts were identified, aiming to offer valuable insights for future investigation.

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来源期刊
International journal of molecular medicine
International journal of molecular medicine 医学-医学:研究与实验
CiteScore
12.30
自引率
0.00%
发文量
124
审稿时长
3 months
期刊介绍: The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.
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