NAKO 健康研究中的基线磁共振成像检查--关于可行性、参与率和辍学率、舒适度和成像质量的结论。

IF 6.5 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Fabian Bamberg, Christopher L Schlett, Svenja Caspers, Steffen Ringhof, Matthias Günther, Jochen G Hirsch, Julia Rüdebusch, Pavlína Miklánková, Nora Bittner, Christiane Jockwitz, Michael Forsting, Norbert Hosten, Rudolph Kaaks, Hans-Ulrich Kauczor, Thomas Kroenke, Thoralf Niendorf, Annette Peters, Tobias Pischon, Andreas Stang, Klaus Berger, Henry Völzke
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引用次数: 0

摘要

背景:磁共振成像(MRI)可提供有关许多不同疾病的发展和现状的重要信息。因此,全身磁共振成像成为多中心、基于人群的 NAKO 健康研究的一部分。本分析涉及 2014-2019 年期间核磁共振基线检查的可行性和质量保证的各个方面。方法:NAKO 健康研究邀请了 32 252 名年龄在 20 至 74 岁之间、无核磁共振禁忌症的参与者在德国的五个核磁共振研究中心之一接受扫描。全身核磁共振成像扫描耗时约一小时,扫描序列包括大脑、肌肉骨骼系统、心血管系统和胸腹系统的结构和功能特征。对不良事件、磁共振成像方案的完整性、参与者的主观感受和图像质量进行了全面的质量保证评估:31 578 名参与者(97.9%)成功参与了磁共振成像研究。结果:31 578 名参与者(97.9%)成功参与了核磁共振成像研究,他们表示非常舒适,没有出现严重的不良反应;只有四名参与者出现了轻微的不良反应。根据成像序列的不同,80.2%至96.8%的病例图像质量被评为优秀。对大脑结构特征的质量评估显示,各研究中心之间的一致性很高,脑容量的年龄和性别差异也很明显(男性,1203.81 ± 102.06 cm³;女性,1068.10 ± 86.69 cm³):结论:全身核磁共振成像已成功应用于 NAKO 基线检查,患者舒适度高,图像质量非常好。大脑成像生物标志物证实了之前观察到的基于年龄和性别的差异,强调了数据汇集的可行性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Baseline MRI Examination in the NAKO Health Study—Findings on Feasibility, Participation and Dropout Rates, Comfort, and Image Quality.

Background: Magnetic resonance imaging (MRI) yields important information on the development and current status of many different diseases. Whole-body MRI was accordingly made a part of the multicenter, population-based NAKO Health Study. The present analysis concerns the feasibility of the baseline MRI examination and various aspects of quality assurance over the period 2014-2019.

Methods: 32 252 participants in the NAKO Health Study, aged 20 to 74, who had no contraindication to MRI were invited to undergo scanning in one of five MRI study centers across Germany. The whole-body MRI scan took about one hour and consisted of sequences for the visualization of structural and functional features of the brain, musculoskeletal system, cardiovascular system, and thoracoabdominal system. A comprehensive quality-assurance assessment was carried out, with evaluation of adverse events, the completeness of the MRI protocols, the participants' subjective perceptions, and image quality.

Results: 31 578 participants (97.9%) were successfully included in the MRI study. They reported a high level of comfort and suffered no severe adverse events (mild adverse events occurred in only four participants). Depending on the imaging sequence, the image quality was rated as excellent in 80.2% to 96.8% of cases. Quality assessment with respect to structural features of the brain revealed high consistency across study centers, as well as with regard to age- and sex-based differences in brain volume (men, 1203.81 ± 102.06 cm³; women, 1068.10 ± 86.69 cm³).

Conclusion: Whole-body MRI was successfully implemented in the NAKO baseline examination and was associated with high patient comfort and very good image quality. The imaging biomarkers of the brain confirmed previously observed differences based on age and sex, underscoring the feasibility of data pooling.

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来源期刊
Deutsches Arzteblatt international
Deutsches Arzteblatt international 医学-医学:内科
CiteScore
4.10
自引率
5.20%
发文量
306
审稿时长
4-8 weeks
期刊介绍: Deutsches Ärzteblatt International is a bilingual (German and English) weekly online journal that focuses on clinical medicine and public health. It serves as the official publication for both the German Medical Association and the National Association of Statutory Health Insurance Physicians. The journal is dedicated to publishing independent, peer-reviewed articles that cover a wide range of clinical medicine disciplines. It also features editorials and a dedicated section for scientific discussion, known as correspondence. The journal aims to provide valuable medical information to its international readership and offers insights into the German medical landscape. Since its launch in January 2008, Deutsches Ärzteblatt International has been recognized and included in several prestigious databases, which helps to ensure its content is accessible and credible to the global medical community. These databases include: Carelit CINAHL (Cumulative Index to Nursing and Allied Health Literature) Compendex DOAJ (Directory of Open Access Journals) EMBASE (Excerpta Medica database) EMNursing GEOBASE (Geoscience & Environmental Data) HINARI (Health InterNetwork Access to Research Initiative) Index Copernicus Medline (MEDLARS Online) Medpilot PsycINFO (Psychological Information Database) Science Citation Index Expanded Scopus By being indexed in these databases, Deutsches Ärzteblatt International's articles are made available to researchers, clinicians, and healthcare professionals worldwide, contributing to the global exchange of medical knowledge and research.
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