环状 RNA 在癌症患者化疗诱发心脏毒性发病机制中的作用:聚焦发病机制与未来展望》。

IF 3.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiovascular Toxicology Pub Date : 2024-11-01 Epub Date: 2024-08-19 DOI:10.1007/s12012-024-09914-w
Pegah Joghataie, Mahya Bakhshi Ardakani, Neda Sabernia, Afshin Salary, Sepehr Khorram, Tooba Sohbatzadeh, Vahid Goodarzi, Bahareh Shateri Amiri
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引用次数: 0

摘要

心脏毒性是当今癌症患者面临的一项严峻挑战。心脏毒性涉及多种因素。环状核糖核酸(circRNA)是发生和预防心脏毒性的有效因素之一。环状核糖核酸可通过调节分子通路以及增加或减少基因表达,导致心肌细胞增殖、凋亡和再生;有些环状核糖核酸在心肌细胞再生或死亡中具有双重作用。确定与这些过程相关的每种途径可有效控制患者病情并预防心脏毒性。本研究概述了 circRNAs 参与心脏毒性的分子通路及其对下游因子的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Role of Circular RNA in the Pathogenesis of Chemotherapy-Induced Cardiotoxicity in Cancer Patients: Focus on the Pathogenesis and Future Perspective.

The Role of Circular RNA in the Pathogenesis of Chemotherapy-Induced Cardiotoxicity in Cancer Patients: Focus on the Pathogenesis and Future Perspective.

Cardiotoxicity is a serious challenge cancer patients face today. Various factors are involved in cardiotoxicity. Circular RNAs (circRNAs) are one of the effective factors in the occurrence and prevention of cardiotoxicity. circRNAs can lead to increased proliferation, apoptosis, and regeneration of cardiomyocytes by regulating the molecular pathways, as well as increasing or decreasing gene expression; some circRNAs have a dual role in cardiomyocyte regeneration or death. Identifying each of the pathways related to these processes can be effective on managing patients and preventing cardiotoxicity. In this study, an overview of the molecular pathways involved in cardiotoxicity by circRNAs and their effects on the downstream factors have been discussed.

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来源期刊
Cardiovascular Toxicology
Cardiovascular Toxicology 医学-毒理学
CiteScore
6.60
自引率
3.10%
发文量
61
审稿时长
>12 weeks
期刊介绍: Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.
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