关于接种 COVID-19 疫苗与少女月经周期特征关系的前瞻性研究。

IF 5.5 2区医学 Q1 PEDIATRICS

Journal of Adolescent Health Pub Date : 2024-08-16 DOI:10.1016/j.jadohealth.2024.06.023

Laura A. Payne Ph.D. , Laura C. Seidman , Steven W. Granger Ph.D. , Alison Edelman M.D., M.P.H. , Boyu Ren Ph.D.

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引用次数: 0

摘要

目的：与未接种COVID-19加强型疫苗的少女相比，本研究旨在评估COVID-19加强型疫苗对少女（13-20岁）月经周期特征的影响：这项前瞻性研究测量了接种疫苗前三个周期和接种疫苗后四个周期（加强接种组）以及未接种疫苗七个周期（对照组）的月经周期长度。对月经量、痛经和月经症状进行基线评估，并在 3 个月内每月进行一次评估。基线时使用 PROMIS 儿科心理压力体验量表对压力进行评估。采用广义线性混合效应模型来研究月经特征的变化：通过社交媒体和美国正在进行的研究招募了 65 名少女（47 名助推组；18 名对照组）。与接受增效剂前相比，接受增效剂组女孩的月经周期平均缩短了 5.35 天（p = .03），尤其是在接受增效剂后的第二个周期，而对照组女孩的月经周期长度在接受增效剂前到接受增效剂后没有任何变化。在卵泡期接受助推剂的参与者，其助推剂后的平均周期长度（p = .0157）比助推剂前更短（p = .0157）。压力越大，周期越短（p = .03），月经症状越多（p = 讨论）：COVID-19加强型疫苗与少女月经周期缩短有关。这些数据表明，有必要进一步研究这些观察到的变化的潜在机制。

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A Prospective Study of the Relationship of COVID-19 Vaccination to Menstrual Cycle Characteristics in Adolescent Girls

Purpose

The current study aimed to evaluate the impact of the COVID-19 booster vaccine on menstrual cycle characteristics in adolescent girls (aged 13–20) compared to those who did not receive a booster vaccine.

Methods

This prospective study measured menstrual cycle length for three cycles prior to and four cycles after vaccination (booster group), seven cycles without vaccination (control group). Menstrual flow, menstrual pain, and menstrual symptoms were assessed at baseline and monthly for 3 months. Stress was assessed at baseline using the PROMIS Pediatric Psychological Stress Experiences scale. Generalized linear mixed effects models were used to examine the changes in menstrual characteristics.

Results

65 adolescent girls (47 booster; 18 control) were recruited via social media and from ongoing studies in the United States. Girls in the booster group experienced shorter postbooster cycles by an average 5.35 days (p = .03) compared to prebooster cycle lengths, specifically in the second postbooster cycle, while the control group did not show any changes in cycle length pre-to postbooster. Participants who received the booster in the follicular phase had shorter mean postbooster cycle length (p = .0157) compared to their prebooster cycle length. Higher stress was associated with shorter cycles (p = .03) and increased menstrual symptoms (p = <.001), regardless of group. There were no differences in menstrual flow, menstrual pain, or menstrual symptoms in either group.

Discussion

The COVID-19 booster vaccine was associated with shorter cycles in adolescent girls. These data demonstrate the need for further investigation regarding potential mechanisms of these observed changes.

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来源期刊

Journal of Adolescent Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

10.40

自引率

3.90%

发文量

526

审稿时长

46 days

期刊介绍： The Journal of Adolescent Health is a scientific publication dedicated to enhancing the health and well-being of adolescents and young adults. Our Journal covers a broad range of research topics, spanning from the basic biological and behavioral sciences to public health and policy. We welcome a variety of contributions, including original research papers, concise reports, literature reviews, clinical case reports, opinion pieces, and letters to the editor. We encourage professionals from diverse disciplines such as Anthropology, Education, Ethics, Global Health, Health Services Research, Law, Medicine, Mental and Behavioral Health, Nursing, Nutrition, Psychology, Public Health and Policy, Social Work, Sociology, and Youth Development to share their expertise and contribute to our mission of promoting adolescent health. Moreover, we value the voices of young individuals, family and community members, and healthcare professionals, and encourage them to submit poetry, personal narratives, images, and other creative works that provide unique insights into the experiences of adolescents and young adults. By combining scientific peer-reviewed research with creative expressions, our Journal aims to create a comprehensive understanding of the challenges and opportunities in adolescent and young adult health.