新型 2.5 MV 烧结金刚石靶束在颅内亚麻加速器立体定向治疗中的应用研究。

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Jennifer M Borsavage, Amanda J Cherpak, James L Robar
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引用次数: 0

摘要

目的:这项研究调查了 2.5 MV 烧结钻石靶光束的小场剂量测定特性及其用于基于线性加速器的颅内立体定向治疗的可行性。由于低Z光束中低能量光子的比例增加,我们假设这种新型光束会比6 MV光束提供更锐利的剂量衰减,原因是次级电子的能量和范围减少了:使用蒙特卡洛模拟 2.5 MV 低 Z 和 6 MV 射束对眼部黑色素瘤和三叉神经痛的立体定向治疗,计算体素化解剖模型中的剂量。研究了两种准直方法,包括 5x3 mm2 HDMLC 磁场和 4 mm 锥体,以展示几何和放射对半影宽度的单独和综合影响:测得的 2.5 MV 低 Z 剂量曲线显示,与 6 MV 相比,两种准直方法在所有深度的内线和横线方向上的半影都减少了 0.5 毫米。在这两种治疗方法中,用 4 毫米锥体准直的 2.5 MV 低 Z 射束在通过等中心捕获的剖面中产生的剂量衰减最明显。与 6 MV 相比,2.5 MV 低 Z MLC 准直光束在三叉神经痛病例中的最大脑干剂量下降了 59%。在眼部黑色素瘤病例中,采用两种准直方法,2.5 MV lowZ 射束的同侧和对侧 OAR 最大剂量和平均剂量均比 6 MV 减少:虽然这种新型射束的剂量率较低,无法立即应用于临床,但本研究结果支持进一步开发这种原型射束,以降低颅内 SRS 治疗的毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigation of a novel 2.5 MV sintered diamond target beam for intracranial linac-based stereotactic treatments.

Purpose. This work investigates the small-field dosimetric characteristics of a 2.5 MV sintered diamond target beam and its feasibility for use in linac-based intracranial stereotactic treatments. Due to the increased proportion of low energy photons in the low-Z beam, it was hypothesized that this novel beam would provide sharper dose fall-off compared to the 6 MV beam owing to the reduced energy, and therefore range, of secondary electrons.Methods. Stereotactic treatments of ocular melanoma and trigeminal neuralgia were simulated for 2.5 MV low-Z and 6 MV beams using Monte Carlo to calculate dose in a voxelized anatomical phantom. Two collimation methods were investigated, including a 5 × 3 mm2HDMLC field and a 4 mm cone to demonstrate isolated and combined effects of geometric and radiological contributions to the penumbral width.Results. The measured 2.5 MV low-Z dosimetric profiles demonstrated reduced penumbra by 0.5 mm in both the inline and crossline directions across all depths for both collimation methods, compared to 6 MV. In both treatment cases, the 2.5 MV low-Z beam collimated with the 4 mm cone produced the sharpest dose fall off in profiles captured through isocenter. This improved fall-off resulted in a 59% decrease to the maximum brainstem dose in the trigeminal neuralgia case for the 2.5 MV low-Z MLC collimated beam compared to 6 MV. Reductions to the maximum and mean doses to ipsilateral and contralateral OARs in the ocular melanoma case were observed for the 2.5 MV low-Z beam compared to 6 MV with both collimation methods.Conclusions. While the low dose rate of this novel beam prohibits immediate clinical translation, the results of this study support the further development of this prototype beam to decrease toxicity in intracranial SRS treatments.

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来源期刊
Biomedical Physics & Engineering Express
Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.80
自引率
0.00%
发文量
153
期刊介绍: BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
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