Yi Ge, Cong Chen, Hong Li, Ruyi Wang, Yuyu Yang, Lingqi Ye, Chenmin He, Ruotong Chen, Zijian Wang, Xiaotong Shao, Yuting Gong, Linglin Yang, Shan Wang, Jiping Zhou, Xunyi Wu, Shuang Wang, Yao Ding
{"title":"颞叶癫痫伴局灶至双侧强直阵挛发作的结构网络改变。","authors":"Yi Ge, Cong Chen, Hong Li, Ruyi Wang, Yuyu Yang, Lingqi Ye, Chenmin He, Ruotong Chen, Zijian Wang, Xiaotong Shao, Yuting Gong, Linglin Yang, Shan Wang, Jiping Zhou, Xunyi Wu, Shuang Wang, Yao Ding","doi":"10.1002/acn3.52135","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>This study aims to investigate whether alterations in white matter topological networks are associated with focal to bilateral tonic–clonic seizures (FBTCS) in temporal lobe epilepsy (TLE). Additionally, we investigated the variables contributing to memory impairment in TLE.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This cross-sectional study included 88 unilateral people with TLE (45 left/43 right), and 42 healthy controls. Graph theory analysis was employed to compare the FBTCS (+) group (<i>n</i> = 51) with the FBTCS (−) group (<i>n</i> = 37). The FBTCS (+) group was subcategorized into current-FBTCS (<i>n</i> = 31) and remote-FBTCS (<i>n</i> = 20), based on the history of FBTCS within 1 year or longer than 1 year before scanning, respectively. We evaluated the discriminatory power of topological network properties by receiver operating characteristic (ROC) analysis. Generalized linear models (GLMs) were employed to investigate variables associated with memory impairment in TLE.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Global efficiency (Eg) was significantly reduced in the FBTCS (+) group, especially in the current-FBTCS subgroup. Greater disruption of regional properties in the ipsilateral occipital and temporal association cortices was observed in the FBTCS (+) group. ROC analysis revealed that Eg, normalized characteristic shortest path length, and nodal efficiency of the ipsilateral middle temporal gyrus could distinguish between FBTCS (+) and FBTCS (−) groups. Additionally, GLMs linked the occurrence of current FBTCS with poorer verbal memory outcomes in TLE.</p>\n </section>\n \n <section>\n \n <h3> Interpretation</h3>\n \n <p>Our study suggests that abnormal networks could be the structural basis of seizure propagation in FBTCS. Strategies aimed at reducing the occurrence of FBTCS could potentially improve the memory outcomes in people with TLE.</p>\n </section>\n </div>","PeriodicalId":126,"journal":{"name":"Annals of Clinical and Translational Neurology","volume":"11 9","pages":"2277-2288"},"PeriodicalIF":4.4000,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acn3.52135","citationCount":"0","resultStr":"{\"title\":\"Altered structural network in temporal lobe epilepsy with focal to bilateral tonic–clonic seizures\",\"authors\":\"Yi Ge, Cong Chen, Hong Li, Ruyi Wang, Yuyu Yang, Lingqi Ye, Chenmin He, Ruotong Chen, Zijian Wang, Xiaotong Shao, Yuting Gong, Linglin Yang, Shan Wang, Jiping Zhou, Xunyi Wu, Shuang Wang, Yao Ding\",\"doi\":\"10.1002/acn3.52135\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>This study aims to investigate whether alterations in white matter topological networks are associated with focal to bilateral tonic–clonic seizures (FBTCS) in temporal lobe epilepsy (TLE). 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Generalized linear models (GLMs) were employed to investigate variables associated with memory impairment in TLE.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Global efficiency (Eg) was significantly reduced in the FBTCS (+) group, especially in the current-FBTCS subgroup. Greater disruption of regional properties in the ipsilateral occipital and temporal association cortices was observed in the FBTCS (+) group. ROC analysis revealed that Eg, normalized characteristic shortest path length, and nodal efficiency of the ipsilateral middle temporal gyrus could distinguish between FBTCS (+) and FBTCS (−) groups. Additionally, GLMs linked the occurrence of current FBTCS with poorer verbal memory outcomes in TLE.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Interpretation</h3>\\n \\n <p>Our study suggests that abnormal networks could be the structural basis of seizure propagation in FBTCS. 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Altered structural network in temporal lobe epilepsy with focal to bilateral tonic–clonic seizures
Objectives
This study aims to investigate whether alterations in white matter topological networks are associated with focal to bilateral tonic–clonic seizures (FBTCS) in temporal lobe epilepsy (TLE). Additionally, we investigated the variables contributing to memory impairment in TLE.
Methods
This cross-sectional study included 88 unilateral people with TLE (45 left/43 right), and 42 healthy controls. Graph theory analysis was employed to compare the FBTCS (+) group (n = 51) with the FBTCS (−) group (n = 37). The FBTCS (+) group was subcategorized into current-FBTCS (n = 31) and remote-FBTCS (n = 20), based on the history of FBTCS within 1 year or longer than 1 year before scanning, respectively. We evaluated the discriminatory power of topological network properties by receiver operating characteristic (ROC) analysis. Generalized linear models (GLMs) were employed to investigate variables associated with memory impairment in TLE.
Results
Global efficiency (Eg) was significantly reduced in the FBTCS (+) group, especially in the current-FBTCS subgroup. Greater disruption of regional properties in the ipsilateral occipital and temporal association cortices was observed in the FBTCS (+) group. ROC analysis revealed that Eg, normalized characteristic shortest path length, and nodal efficiency of the ipsilateral middle temporal gyrus could distinguish between FBTCS (+) and FBTCS (−) groups. Additionally, GLMs linked the occurrence of current FBTCS with poorer verbal memory outcomes in TLE.
Interpretation
Our study suggests that abnormal networks could be the structural basis of seizure propagation in FBTCS. Strategies aimed at reducing the occurrence of FBTCS could potentially improve the memory outcomes in people with TLE.
期刊介绍：
Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.
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