脊髓损伤对成本和与健康相关的生活质量的影响的系统回顾。

IF 2 Q2 ECONOMICS
PharmacoEconomics Open Pub Date : 2024-11-01 Epub Date: 2024-08-16 DOI:10.1007/s41669-024-00517-3
Modou Diop, David Epstein
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引用次数: 0

摘要

目的系统回顾脊髓损伤(SCI)对医疗服务、患者和社会造成的健康相关生活质量(HRQoL)负担和成本:2021 年 3 月,我们通过 Scopus、PubMed 和 Embase 数据库,在《系统综述和元分析首选报告项目声明》的指导下开展了一项系统综述。纳入标准为报告医疗成本、社会成本和/或用 Euroqol EQ-5D 或 Short-Form 36 测量的 HRQoL 的 SCI 定量研究。使用QualSyst工具评估偏倚风险。进行了描述性分析、随机效应直接荟萃分析和随机效应荟萃回归分析:共有 67 项研究符合纳入条件。SCI患者报告的HRQoL中,精神方面往往高于身体方面。SCI 的神经水平对 HRQoL 有负面影响。横向研究发现,就业与较好的 HRQoL 有关,但纵向研究未观察到这种影响。每名 SCI 患者的终生估计支出从 70 万美元到 250 万美元不等,受伤年龄越早、神经水平越高、美国医疗保健环境越好以及研究中包含非医疗保健项目的成本越高:结论:SCI 与活动能力和身体方面的 HRQoL 低下有关。心理健康得分往往高于身体健康得分,大多数方面的 HRQoL 似乎会随着时间的推移而改善,至少在第一年是如此。SCI 与高昂的费用有关,费用因国家而异:本综述已在 PROSPERO 注册(注册号:CRD42021235801)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Systematic Review of the Impact of Spinal Cord Injury on Costs and Health-Related Quality of Life.

Objective: To systematically review the health-related quality of life (HRQoL) burden and costs of spinal cord injury (SCI) on health services, patients and wider society.

Methods: A systematic review guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement was conducted in March 2021 through Scopus, PubMed and Embase databases. Inclusion criteria were quantitative studies on SCI reporting healthcare costs, social costs and/or HRQoL measured with the Euroqol EQ-5D or Short-Form 36. Risk of bias was assessed using the QualSyst tool. Descriptive analyses, random-effects direct meta-analysis and random-effects meta-regression were conducted.

Results: A total of 67 studies were eligible for inclusion. SCI individuals tend to report higher HRQoL in mental than physical dimensions of the Short-Form 36. Neurological level of SCI negatively affects HRQoL. Cross-sectional studies find employment is associated with better HRQoL, but the effect is not observed in longitudinal studies. The estimated lifetime expenditure per individual with SCI ranged from US$0.7 million to US$2.5 million, with greater costs associated with earlier age at injury, neurological level, United States of America healthcare setting and the inclusion of non-healthcare items in the study.

Conclusions: SCI is associated with low HRQoL on mobility and physical dimensions. Mental health scores tend to be greater than physical scores, and most dimensions of HRQoL appear to improve over time, at least over the first year. SCI is associated with high costs which vary by country.

Clinical trials registration: This review was registered in PROSPERO (registration number: CRD42021235801).

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来源期刊
CiteScore
3.50
自引率
0.00%
发文量
64
审稿时长
8 weeks
期刊介绍: PharmacoEconomics - Open focuses on applied research on the economic implications and health outcomes associated with drugs, devices and other healthcare interventions. The journal includes, but is not limited to, the following research areas:Economic analysis of healthcare interventionsHealth outcomes researchCost-of-illness studiesQuality-of-life studiesAdditional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in PharmacoEconomics -Open may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances.All manuscripts are subject to peer review by international experts. Letters to the Editor are welcomed and will be considered for publication.
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