使用 Kahook 双刀进行割除性神经节切除术的临床效果：6 年结果。

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-10-01 Epub Date: 2024-08-16 DOI:10.1007/s40123-024-01016-8

Pranav Vasu, Yazan Abubaker, Nithya Boopathiraj, Isabella V Wagner, P Connor Lentz, Emily Dorairaj, Aya Shokair, Ibrahim Qozat, Darby D Miller, Syril Dorairaj

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引用次数: 0

摘要

简介：本研究旨在评估在治疗各种类型的青光眼时使用 Kahook 双刀（KDB）进行眼球切开术的长期临床效果：本研究旨在评估使用 Kahook 双刀（KDB）进行眼球切开术治疗各种类型青光眼的长期临床疗效：这是对2015年10月至2017年10月期间53名青光眼患者的90只眼睛进行的回顾性、非比较性病历回顾，这些患者接受了独立的KDB开孔术（KDB-onalone组）或KDB开孔术并同时进行了乳化术（KDB-phaco组）。手术成功的定义是：最后一次随访时眼压（IOP）降低≥20%，且无需再次手术干预，最终眼压≥4 mmHg且≤21 mmHg。我们还报告了 72 个月内眼压、青光眼用药次数、最佳矫正视力（BCVA）和视野参数与基线相比的变化情况：结果：72 个月后，平均（标准差 [SD]）眼压从 17.5（5.7）毫米汞柱降至 13.6（3.0）毫米汞柱（P 结论：眼压降低的主要原因是青光眼药物的数量减少：使用 KDB 进行切除性开颅手术能有效降低眼压（与基线值相比平均降低 28.0%），维持或进一步减少青光眼药物负担（与基线值相比平均降低 30.8%），且安全性极佳，不受超声乳化状态的影响。该手术在长达 6 年的时间里取得了良好的成功，为其作为青光眼治疗方法的长期疗效提供了宝贵的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Clinical Outcomes of Excisional Goniotomy with the Kahook Dual Blade: 6-Year Results.

查看原文本刊更多论文

Clinical Outcomes of Excisional Goniotomy with the Kahook Dual Blade: 6-Year Results.

Introduction: This study aims to evaluate the long-term clinical outcomes of excisional goniotomy with the Kahook Dual Blade (KDB) in the management of various types of glaucoma.

Methods: This was a retrospective, noncomparative chart review of 90 eyes of 53 patients with glaucoma that underwent standalone KDB goniotomy (KDB-alone group) or KDB goniotomy with concomitant phacoemulsification (KDB-phaco group) between October 2015 and October 2017. Surgical success was defined as an intraocular pressure (IOP) reduction by ≥ 20% at the last follow-up with no surgical reinterventions required and a final IOP ≥ 4 mmHg and ≤ 21 mmHg. We also report on changes from baseline in IOP, number of glaucoma medications, best-corrected visual acuity (BCVA), and visual field parameters, for up to 72 months.

Results: At 72 months, mean (standard deviation [SD]) IOP was reduced from 17.5 (5.7) to 13.6 (3.0) mmHg (P < 0.0001) in the KDB-phaco group and from 23.3 (5.9) to 15.1 (6.2) mmHg (P = 0.0593) in the KDB-alone group. The mean (SD) number of glaucoma medications was reduced from 1.3 (1.0) to 0.8 (0.9) (P < 0.0001) in the KDB-phaco group and from 1.2 (1.0) to 0.7 (0.8) (P = 0.3409) in the KDB-alone group. During the 72-month follow-up, surgical success was achieved in 24 of the 52 available eyes (46.2%). Four eyes underwent a glaucoma surgical reintervention by 72 months.

Conclusions: Excisional goniotomy with the KDB effectively lowered the IOP (by an average of 28.0% from baseline) and maintained or further reduced glaucoma medication burdens (by an average of 30.8% from baseline) under an excellent safety profile, independent of phacoemulsification status. The procedure exhibited favorable success for up to 6 years, providing valuable insights into its long-term efficacy as a glaucoma treatment.

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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