强脉冲光疗法对干眼症患者眼表健康和泪膜动力学的长期影响：一年随访期的详细分析和观察。

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-10-01 Epub Date: 2024-08-16 DOI:10.1007/s40123-024-01017-7

Cristina-Patricia Pac, Mihnea Munteanu, José-María Sánchez-González, Carlos Rocha-de-Lossada, Nadina Mercea, Francis Ferrari, Horia T Stanca, Dan Andrei Radu Cosnita, Mihaela Ionica, Ovidiu Boruga, Ciprian Danielescu, Alexandru Blidisel

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引用次数: 0

摘要

简介：目的：评估强脉冲光疗法对伴有睑板腺功能障碍（MGD）的干眼症（DED）患者的长期影响：评估强脉冲光（IPL）疗法对伴有睑板腺功能障碍（MGD）的干眼症（DED）患者的长期影响：方法：对110名接受强脉冲光治疗的患者进行了回顾性病例系列研究。方法：对接受 IPL 治疗的 110 名参与者进行了回顾性病例系列研究。评估包括眼部健康测试 (EFT)，以衡量主观症状，以及使用 Tearcheck® 设备（ESW Vision，法国胡丹）进行的客观测量，包括无创首次泪液破裂时间 (NIFBUT)、无创平均泪液破裂时间 (NIABUT)、中心泪液半月板高度（CTMH）、最薄泪液半月板高度（TTMH），以及使用 SCHWIND SIRIUS 设备（SCHWIND eye-tech-solutions GmbH，德国 Kleinostheim）进行的眼表炎症风险评估（OSIE）。研究结果这项研究表明，与 DED 和 MGD 相关的主观和客观症状均有明显改善。通过 EFT 测量的主观症状平均增加了 9.74 分（范围为-10 至 28，标准差 [SD] ± 7.54），表明症状有所减轻。以 NIABUT 为代表的泪膜稳定性客观指标平均增加了 4.04 秒（范围-15.00 至 14.40，标准差 ± 4.91）。泪膜稳定性评估（TFSE）得分平均降低了 229.12 分（范围为 -1775-528，标准差 ± 384.94），表明泪膜稳定性增强。OSIE 1 型显示炎症有所减轻，百分比下降了 4.98%（范围-45 至 5，标准差 ± 7.33）。此外，OSIE捕捉时间平均减少了3.25秒（范围-27至22，标准差±10.35），进一步表明眼表健康得到了改善：结论：IPL疗法通过有效控制症状和稳定泪膜，被证明是改善DED患者生活质量的一种很有前景的非侵入性方法。研究结果支持将 IPL 作为一种可持续的治疗方式，用于治疗伴有 MGD 的 DED。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Long-Term Impacts of Intense Pulsed Light Therapy on Ocular Surface Health and Tear Film Dynamics in Patients with Dry Eye Disease: Detailed Analysis and Observations Over a 1-Year Follow-Up Period.

查看原文本刊更多论文

Long-Term Impacts of Intense Pulsed Light Therapy on Ocular Surface Health and Tear Film Dynamics in Patients with Dry Eye Disease: Detailed Analysis and Observations Over a 1-Year Follow-Up Period.

Introduction: To evaluate the long-term effects of intense pulsed light (IPL) therapy on patients with dry eye disease (DED) associated with meibomian gland dysfunction (MGD).

Methods: A retrospective case series was performed with 110 participants undergoing IPL therapy. Assessments included the eye fitness test (EFT) to gauge subjective symptoms, along with objective measures using the Tearcheck^® device (ESW Vision, Houdan, France) noninvasive first breakup time (NIFBUT), noninvasive average breakup time (NIABUT), central tear meniscus height (CTMH), thinnest tear meniscus height (TTMH), and ocular surface inflammatory risk evaluation (OSIE) assessed using the SCHWIND SIRIUS device (SCHWIND eye-tech-solutions GmbH, Kleinostheim, Germany).

Results: This study documented significant improvements in subjective and objective symptoms associated with DED and MGD. Subjective symptoms measured by the EFT showed an average increase of 9.74 points (range -10 to 28, standard deviation [SD] ± 7.54), indicating reduced symptoms. Objective measures of tear film stability, represented by NIABUT, increased by an average of 4.04 s (range -15.00 to 14.40, SD ± 4.91). Tear film stability evaluation (TFSE) scores decreased by 229.12 points on average (range -1775 to 528, SD ± 384.94), suggesting enhanced tear film stability. OSIE type 1 showed a reduction in inflammation, with a percentage decrease of 4.98% (range -45 to 5, SD ± 7.33). Additionally, OSIE capture time decreased by 3.25 s on average (range -27 to 22, SD ± 10.35), further indicating an improvement in ocular surface health.

Conclusion: IPL therapy was shown to be a promising, noninvasive approach for improving quality of life in patients with DED by effectively managing symptoms and stabilizing tear film. The findings support the use of IPL as a sustainable treatment modality for DED associated with MGD.

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. Rapid Publication The journal’s publication timelines aim for a rapid peer review of 2 weeks. If an article is accepted it will be published 3–4 weeks from acceptance. The rapid timelines are achieved through the combination of a dedicated in-house editorial team, who manage article workflow, and an extensive Editorial and Advisory Board who assist with peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid, efficient communication of the latest research and reviews, fostering the advancement of ophthalmic therapies. Open Access All articles published by Ophthalmology and Therapy are open access. Personal Service The journal’s dedicated in-house editorial team offer a personal “concierge service” meaning authors will always have an editorial contact able to update them on the status of their manuscript. The editorial team check all manuscripts to ensure that articles conform to the most recent COPE, GPP and ICMJE publishing guidelines. This supports the publication of ethically sound and transparent research. Digital Features and Plain Language Summaries Ophthalmology and Therapy offers a range of additional features designed to increase the visibility, readership and educational value of the journal’s content. Each article is accompanied by key summary points, giving a time-efficient overview of the content to a wide readership. Articles may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand the scientific content and overall implications of the article. The journal also provides the option to include various types of digital features including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations. All additional features are peer reviewed to the same high standard as the article itself. If you consider that your paper would benefit from the inclusion of a digital feature, please let us know. Our editorial team are able to create high-quality slide decks and infographics in-house, and video abstracts through our partner Research Square, and would be happy to assist in any way we can. For further information about digital features, please contact the journal editor (see ‘Contact the Journal’ for email address), and see the ‘Guidelines for digital features and plain language summaries’ document under ‘Submission guidelines’. 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